Testing Data
(Wholemount frog embryo (8 cell stage) (animal-vegetal plane) stained with MBS615400. Note the localization of ductin (blue signal) to the cell membrane of the animal pole cells. Photo courtesy of Dr. Michael Levin, Forsyth Institute.)
Rabbit anti-Human Ductin Polyclonal Antibody | anti-Dmbt1 antibody
Ductin (Vha16, EP2372, V-ATPase, VHA, Vha1, vha16, vha16-1, VHA16K, Vhac)
Purified by affinity chromatography.
Purified by affinity chromatography.
Dilution: Western Blot: 1:500-1:1000
Immunocytochemistry: 1:100-1:500
Immunohistochemistry: 1:100-1:500 on frog and 1:100-1:2000 on chicken.
Testing Data
(Wholemount frog embryo (8 cell stage) (animal-vegetal plane) stained with MBS615400. Note the localization of ductin (blue signal) to the cell membrane of the animal pole cells. Photo courtesy of Dr. Michael Levin, Forsyth Institute.)
Testing Data
(Wholemount frog embryo (8 cell stage) (animal-vegetal plane) stained with MBS615400. Note the localization of ductin (blue signal) to the cell membrane of the animal pole cells. Photo courtesy of Dr. Michael Levin, Forsyth Institute.)
NCBI and Uniprot Product Information
Uniprot Description
DMBT1: May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly- sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell. Defects in DMBT1 are involved in the development of glioma (GLM). Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Homozygous deletions may be the predominant mechanism of DMBT1 inactivation playing a role in carcinogenesis. DMBT1 is deleted in medulloblastoma and glioblastoma cell lines; point mutations have also been reported in patients with glioma. A loss or reduction of DMBT1 expression has been seen in esophageal, gastric, lung and colorectal carcinomas as well. Belongs to the DMBT1 family. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Oncoprotein; Tumor suppressor; Secreted, signal peptide; Secreted
Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; phagocytic vesicle membrane; zymogen granule membrane; extrinsic to membrane; membrane; cytoplasm; integral to membrane; extracellular region; intracellular; cytoplasmic vesicle
Molecular Function: protein binding; scavenger receptor activity
Biological Process: blastocyst development; protein transport; transport; multicellular organismal development; positive regulation of epithelial cell differentiation; cell differentiation; inner cell mass cell proliferation
Research Articles on Dmbt1
Similar Products
Product Notes
The Dmbt1 dmbt1 (Catalog #AAA615400) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Ductin (Vha16, EP2372, V-ATPase, VHA, Vha1, vha16, vha16-1, VHA16K, Vhac) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Ductin can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC). Suitable for use in ELISA, Western Blot, Immunocytochemistry and Immunohistochemistry. Dilution: Western Blot: 1:500-1:1000 Immunocytochemistry: 1:100-1:500 Immunohistochemistry: 1:100-1:500 on frog and 1:100-1:2000 on chicken. Researchers should empirically determine the suitability of the Dmbt1 dmbt1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Ductin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
