Testing Data
(Wholemount frog embryo (8 cell stage) (animal-vegetal plane) stained withMBS615400. Note the localization of ductin (blue signal) to the cell membrane of the animal pole cells. Photo courtesy of Dr. Michael Levin, Forsyth Institute.)
Rabbit anti-Human Ductin Polyclonal Antibody | anti-ATP6V0C antibody
Ductin (Vha16, EP2372, V-ATPase, VHA, Vha1, vha16, vha16-1, VHA16K, Vhac) (MaxLight 405)
WB: 1:500-1:1000
IHC: 1:100-1:500 on frog and 1:100-1:2000 on chicken.
Applications are based on unconjugated antibody.
Testing Data
(Wholemount frog embryo (8 cell stage) (animal-vegetal plane) stained withMBS615400. Note the localization of ductin (blue signal) to the cell membrane of the animal pole cells. Photo courtesy of Dr. Michael Levin, Forsyth Institute.)
Testing Data
(Wholemount frog embryo (8 cell stage) (animal-vegetal plane) stained withMBS615400. Note the localization of ductin (blue signal) to the cell membrane of the animal pole cells. Photo courtesy of Dr. Michael Levin, Forsyth Institute.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]
Uniprot Description
ATP6V0C: Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the V-ATPase proteolipid subunit family.
Protein type: Transporter, iron; Transporter, ion channel; Membrane protein, integral; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: phagocytic vesicle membrane; focal adhesion; lysosomal membrane; integral to membrane; endosome membrane
Molecular Function: protein binding; ubiquitin protein ligase binding; hydrogen ion transporting ATP synthase activity, rotational mechanism; hydrogen ion transporting ATPase activity, rotational mechanism
Biological Process: interaction with host; proton transport; viral reproduction; cellular iron ion homeostasis; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; transmembrane transport; positive regulation of Wnt receptor signaling pathway
Research Articles on ATP6V0C
Similar Products
Product Notes
The ATP6V0C atp6v0c (Catalog #AAA6473093) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Ductin (Vha16, EP2372, V-ATPase, VHA, Vha1, vha16, vha16-1, VHA16K, Vhac) (MaxLight 405) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Ductin can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA). ICC: 1:100-1:500 WB: 1:500-1:1000 IHC: 1:100-1:500 on frog and 1:100-1:2000 on chicken. Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the ATP6V0C atp6v0c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Ductin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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