Rabbit anti-Human DTX1 Polyclonal Antibody | anti-DTX1 antibody

DTX1 Antibody

Cat. Num. AAA7105313

• Gene Names: DTX1; hDx-1; RNF140
• Reactivity: Human
• Applications: ELISA, Immunofluorescence
• Purity: >95%, Protein G purified
• Synonyms: DTX1; Polyclonal Antibody; DTX1 Antibody; E3 ubiquitin-protein ligase DTX1; Protein deltex-1; Deltex1; hDTX1; RING-type E3 ubiquitin transferase DTX1Curated; anti-DTX1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 620

• Applicable Applications for anti-DTX1 antibody: ELISA (EIA), Immunofluorescence (IF)
• Application Notes: IF: 1:50-1:200
• Immunogen: Recombinant Human E3 ubiquitin-protein ligase DTX1 protein (261-410AA)
• Conjugation: Non-conjugated
• Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunofluorescence (IF)

(Immunofluorescent analysis of Hela cells using MBS7105313 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))

Related Product Information for anti-DTX1 antibody

Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.

Product Categories/Family for anti-DTX1 antibody

Epigenetics and Nuclear Signaling; Neuroscience; Cell biology

NCBI and Uniprot Product Information

• NCBI GI #: 41352718
• NCBI GeneID: 1840
• NCBI Accession #: NP_004407.2
• NCBI GenBank Nucleotide #: NM_004416.2
• UniProt Accession #: Q86Y01; O60630; Q9BS04
• Molecular Weight: 67,368 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase DTX1
• NCBI Official Synonym Full Names: deltex E3 ubiquitin ligase 1
• NCBI Official Symbol: DTX1
• NCBI Official Synonym Symbols: hDx-1; RNF140
• NCBI Protein Information: E3 ubiquitin-protein ligase DTX1
• UniProt Protein Name: E3 ubiquitin-protein ligase DTX1
• Protein Family: Protein DETOXIFICATION
• UniProt Gene Name: DTX1
• UniProt Synonym Gene Names: Deltex1; hDTX1

NCBI Description

Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq, Jul 2008]

Uniprot Description

Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.