Rabbit DPP6 / Dipeptidylpeptidase 6 Polyclonal Antibody | anti-DPP6 antibody

Rabbit Polyclonal to Human DPP6 / Dipeptidylpeptidase 6

Cat. Num. AAA247619

• Gene Names: DPP6; VF2; DPPX
• Reactivity: Chimpanzee, Gorilla, Human; Predicted Reactivity: Gibbon, Monkey (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: DPP6 / Dipeptidylpeptidase 6; Polyclonal Antibody; Rabbit Polyclonal to Human DPP6 / Dipeptidylpeptidase 6; Anti-DPP6 / Dipeptidylpeptidase 6 Antibody (Internal) IHC-plus; DPP6; Dipeptidylpeptidase VI; Dipeptidyl peptidase 6; Dipeptidyl peptidase VI; Dipeptidyl-peptidase 6; Dipeptidylpeptidase 6; DPP VI; DPPX; VF2; Human DPP6; anti-DPP6 antibody

• Host: Rabbit
• Reactivity: Chimpanzee, Gorilla, Human; Predicted Reactivity: Gibbon, Monkey (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human DPP6. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 865

• Applicable Applications for anti-DPP6 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (10 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 18 amino acid peptide from near the center of human DPP6. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla (100%); Gibbon, Monkey (94%); Horse (89%); Panda, Bovine (83%).
• Immunogen Type: Synthetic peptide
• Immunogen: DPP6 / Dipeptidylpeptidase 6 antibody was raised against synthetic 18 amino acid peptide from near the center of human DPP6. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla (100%); Gibbon, Monkey (94%); Horse (89%); Panda, Bovine (83%).
• Antigen Modification: Internal
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-DPP6 antibody IHC of human brain, neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Product Categories/Family for anti-DPP6 antibody

Family: Protease; Subfamily: Serine S9B

NCBI and Uniprot Product Information

• NCBI GI #: 86792774
• NCBI GeneID: 1804
• NCBI Accession #: NP_570629.2
• NCBI GenBank Nucleotide #: NM_130797.3
• UniProt Accession #: P42658
• Molecular Weight: 91,341 Da
• NCBI Official Full Name: dipeptidyl aminopeptidase-like protein 6 isoform 1
• NCBI Official Synonym Full Names: dipeptidyl-peptidase 6
• NCBI Official Symbol: DPP6
• NCBI Official Synonym Symbols: VF2; DPPX
• NCBI Protein Information: dipeptidyl aminopeptidase-like protein 6; DPP VI; dipeptidyl peptidase VI; dipeptidyl peptidase IV-related protein; dipeptidyl aminopeptidase IV-related protein
• UniProt Protein Name: Dipeptidyl aminopeptidase-like protein 6
• Protein Family: Dipeptidyl aminopeptidase-like protein
• UniProt Gene Name: DPP6
• UniProt Synonym Gene Names: DPP VI
• UniProt Entry Name: DPP6_HUMAN

NCBI Description

This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Uniprot Description

DPP6: May be involved in the physiological processes of brain function. Has no dipeptidyl aminopeptidase activity. May modulate the cell surface expression and the activity of the potassium channel KCND2. Defects in DPP6 are the cause of familial paroxysmal ventricular fibrillation type 2 (VF2). A cardiac arrhythmia marked by fibrillary contractions of the ventricular muscle due to rapid repetitive excitation of myocardial fibers without coordinated contraction of the ventricle and by absence of atrial activity. A genetic variation 340 bases upstream from the ATG start site of the DPP6 gene is the cause of familial paroxysmal ventricular fibrillation type 2. Belongs to the peptidase S9B family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q36.2

Cellular Component: voltage-gated potassium channel complex; integral to membrane; plasma membrane

Molecular Function: potassium channel regulator activity; dipeptidyl-peptidase activity; serine-type peptidase activity

Biological Process: generation of action potential; proteolysis

Disease: Ventricular Fibrillation, Paroxysmal Familial, 2; Mental Retardation, Autosomal Dominant 33