Rabbit Dopamine Receptor D3 Polyclonal Antibody | anti-Drd3 antibody
Dopamine Receptor D3 Antibody BIOTIN-Conjugated
ELISA: 1:50,000
Immunofluorescence: Use at a concentration of 5 ug/ul
Immunoprecipitation: Use at an assay dependent dilution. 2ul of this antibody will immunoprecipitate 65-80% dopamine recombinant D3 receptor protein from COS1 cells.
Western Blot: 1:1,000-1:1,5000
Sequence: CQACHVSPELYRATTWGY
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation (By similarity).
NCBI and Uniprot Product Information
NCBI Description
may be involved in facilitating the effects of antipsychotic drugs and drug treatments for Parkinson's disease [RGD, Feb 2006]
Uniprot Description
DRD3: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. Genetic variation in DRD3 is associated with essential tremor hereditary type 1 (ETM1). ETM1 is the most common movement disorder. The main feature is postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: apical part of cell; cell projection; endocytic vesicle; integral to plasma membrane; membrane; plasma membrane
Molecular Function: D1 dopamine receptor binding; dopamine binding; dopamine D1 receptor-like receptor activity; dopamine D2 receptor-like receptor activity; dopamine receptor activity; drug binding; protein binding; protein domain specific binding
Biological Process: acid secretion; arachidonic acid secretion; behavioral response to cocaine; cellular calcium ion homeostasis; circadian regulation of gene expression; dopamine receptor signaling pathway; dopamine receptor, adenylate cyclase activating pathway; dopamine receptor, adenylate cyclase inhibiting pathway; G-protein coupled receptor internalization; G-protein coupled receptor protein signaling pathway; locomotory behavior; musculoskeletal movement, spinal reflex action; negative regulation of adenylate cyclase activity; negative regulation of blood pressure; negative regulation of dopamine receptor signaling pathway; negative regulation of oligodendrocyte differentiation; negative regulation of protein kinase B signaling cascade; negative regulation of protein secretion; negative regulation of sodium:hydrogen antiporter activity; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell proliferation; positive regulation of cytokinesis; positive regulation of dopamine receptor signaling pathway; positive regulation of mitosis; positive regulation of transcription from RNA polymerase II promoter; prepulse inhibition; regulation of cAMP metabolic process; regulation of circadian sleep/wake cycle, sleep; regulation of dopamine secretion; regulation of lipid metabolic process; regulation of locomotion; regulation of multicellular organism growth; renin-angiotensin regulation of blood volume; response to amphetamine; response to cocaine; response to drug; response to ethanol; response to morphine; synaptic transmission, dopaminergic; visual learning
Research Articles on Drd3
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Product Notes
The Drd3 drd3 (Catalog #AAA541394) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Dopamine Receptor D3 Antibody BIOTIN-Conjugated reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Dopamine Receptor D3 can be used in a range of immunoassay formats including, but not limited to, Dot Blot (DB), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB). Dot Blot: 1:50,000 ELISA: 1:50,000 Immunofluorescence: Use at a concentration of 5 ug/ul Immunoprecipitation: Use at an assay dependent dilution. 2ul of this antibody will immunoprecipitate 65-80% dopamine recombinant D3 receptor protein from COS1 cells. Western Blot: 1:1,000-1:1,5000. Researchers should empirically determine the suitability of the Drd3 drd3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Dopamine Receptor D3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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