Rabbit anti-Rat Dopamine Receptor, D1a Polyclonal Antibody | anti-DRD1 antibody
Dopamine Receptor, D1a
Purified by affinity chromatography.
Purified by affinity chromatography.
Dilution: Western Blot (Chemiluminescence): 1-10ug/ml Detects 2 bands of 50 and 75kD in solubilized hippocampal membranes. The 75kD band was not visible in striatum. ~100-400ug of protein/lane should be loaded to visualize the 75kD band that is present in relatively small amounts.
ELISA: 0.5-1.0ug/ml using 1ug/ml of control peptide per well
Immunohistochemistry: 2-10ug/ml on paraformaldehyde fixed tissue sections. D1R has been localized in various regions of the rat brain.
Optimal dilution determined by the researcher.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
DRD1: a G-protein coupled receptor.One of the five types (D1 to D5) of receptors for dopamine. The most abundant dopamine receptor in the central nervous system. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Interacts with calcyon.
Protein type: Membrane protein, integral; GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 5q35.1
Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane; plasma membrane; nucleus
Molecular Function: protein binding; dopamine receptor activity; dopamine binding; dopamine D1 receptor-like receptor activity
Biological Process: synaptic transmission, dopaminergic; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); peristalsis; behavioral fear response; prepulse inhibition; positive regulation of potassium ion transport; generation of action potential; thermoregulation; dopamine metabolic process; vasodilation; adult walking behavior; G-protein signaling, adenylate cyclase activating pathway; positive regulation of synaptic transmission, glutamatergic; synaptogenesis; protein import into nucleus; behavioral response to cocaine; conditioned taste aversion; positive regulation of cAMP biosynthetic process; visual learning; dopamine receptor, adenylate cyclase activating pathway; response to drug; grooming behavior; dopamine transport; dentate gyrus development; striatum development; cerebral cortex GABAergic interneuron migration; maternal behavior; response to amphetamine; regulation of dopamine metabolic process; adenylate cyclase activation; regulation of dopamine uptake; mating behavior; transmission of nerve impulse; astrocyte development; memory; G-protein signaling, coupled to cyclic nucleotide second messenger; habituation; glucose import; operant conditioning; sensitization; positive regulation of release of sequestered calcium ion into cytosol; dopamine receptor, phospholipase C activating pathway; positive regulation of cell migration
Research Articles on DRD1
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Product Notes
The DRD1 drd1 (Catalog #AAA629337) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Dopamine Receptor, D1a reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Dopamine Receptor, D1a can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in Western Blot, Immunohistochemistry and ELISA. Dilution: Western Blot (Chemiluminescence): 1-10ug/ml Detects 2 bands of 50 and 75kD in solubilized hippocampal membranes. The 75kD band was not visible in striatum. ~100-400ug of protein/lane should be loaded to visualize the 75kD band that is present in relatively small amounts. ELISA: 0.5-1.0ug/ml using 1ug/ml of control peptide per well Immunohistochemistry: 2-10ug/ml on paraformaldehyde fixed tissue sections. D1R has been localized in various regions of the rat brain. Optimal dilution determined by the researcher. Researchers should empirically determine the suitability of the DRD1 drd1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Dopamine Receptor, D1a, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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