Western Blot (WB)
(DOK7 Antibody (N-term) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the DOK7 antibody detected the DOK7 protein (arrow).)
Rabbit anti-Mouse DOK7 Polyclonal Antibody | anti-DOK7 antibody
DOK7 Antibody (N-term)
Western Blot (WB)
(DOK7 Antibody (N-term) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the DOK7 antibody detected the DOK7 protein (arrow).)
Western Blot (WB)
(DOK7 Antibody (N-term) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the DOK7 antibody detected the DOK7 protein (arrow).)
neuromuscular synaptogenesis. The protein functions in aneural
activation of muscle-specific receptor kinase, which is required
for postsynaptic differentiation, and in the subsequent clustering
of the acetylcholine receptor in myotubes. This protein can also
induce autophosphorylation of muscle-specific receptor kinase.
Mutations in this gene are a cause of familial limb-girdle
myasthenia autosomal recessive, which is also known as congenital
myasthenic syndrome type 1B. Alternative splicing results in
multiple transcript variants.
Srour, M., et al. Neuromuscul. Disord. 20(7):453-457(2010)
Maselli, R.A., et al. Hum. Mol. Genet. 19(12):2370-2379(2010)
Ben Ammar, A., et al. J. Neurol. 257(5):754-766(2010)
Vogt, J., et al. J. Med. Genet. 46(5):338-340(2009)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Uniprot Description
DOK7: docking proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK. Interacts with the cytoplasmic part of MUSK. Defects in DOK7 are the cause of congenital myasthenic syndrome type 1B or CMS1B. Three isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold; Activator
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component: plasma membrane; cell junction; neuromuscular junction
Molecular Function: protein kinase binding; insulin receptor binding; phosphoinositide binding
Biological Process: receptor clustering; neuromuscular junction development
Disease: Myasthenia, Limb-girdle, Familial; Fetal Akinesia Deformation Sequence
Research Articles on DOK7
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Product Notes
The DOK7 dok7 (Catalog #AAA9212612) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 26-55. The DOK7 Antibody (N-term) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's DOK7 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the DOK7 dok7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DOK7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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