Rabbit anti-Human DOC2B Polyclonal Antibody | anti-DOC2B antibody

DOC2B Antibody, HRP conjugated

Cat. Num. AAA7050201

• Gene Names: DOC2B; DOC2BL
• Reactivity: Human
• Applications: ELISA
• Purity: >95%, Protein G purified
• Synonyms: DOC2B; Polyclonal Antibody; DOC2B Antibody; HRP conjugated; Double C2-like domain-containing protein betaDoc2-beta; DOC2BL; anti-DOC2B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 412

• Applicable Applications for anti-DOC2B antibody: ELISA (EIA)
• Immunogen: Recombinant Human Double C2-like domain-containing protein beta protein (7-180AA)
• Preservative: 0.03% Proclin 300
• Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugation: HRP
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Related Product Information for anti-DOC2B antibody

Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 295054132
• NCBI GeneID: 8447
• NCBI Accession #: NP_003576.2
• NCBI GenBank Nucleotide #: NM_003585.4
• UniProt Accession #: Q14184
• Molecular Weight: 45,949 Da
• NCBI Official Full Name: double C2-like domain-containing protein beta
• NCBI Official Synonym Full Names: double C2 domain beta
• NCBI Official Symbol: DOC2B
• NCBI Official Synonym Symbols: DOC2BL
• NCBI Protein Information: double C2-like domain-containing protein beta
• UniProt Protein Name: Double C2-like domain-containing protein beta
• Protein Family: Double C2-like domain-containing protein
• UniProt Gene Name: DOC2B
• UniProt Synonym Gene Names: DOC2BL; Doc2-beta
• UniProt Entry Name: DOC2B_HUMAN

NCBI Description

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells. [provided by RefSeq, Jul 2008]

Uniprot Description

DOC2B: Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: cytoplasm; plasma membrane; SNARE complex

Molecular Function: calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; syntaxin binding

Biological Process: calcium ion-dependent exocytosis of neurotransmitter; positive regulation of calcium ion-dependent exocytosis; positive regulation of insulin secretion; positive regulation of vesicle fusion; protein localization; regulation of calcium ion-dependent exocytosis; vesicle fusion