Western Blot (WB)
(Western blot analysis of DNMT1 with lysate from rat kidney tissue (Lane 1), 3T3 cells (Lane 2) and Jurkat cell lysates (Lane 3 & 4).)
Rabbit DNMT1 Polyclonal Antibody | anti-DNMT1 antibody
DNMT1 Antibody
Gene Names
DNMT1; AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; m.HsaI
Applications
Western Blot
Purity
Affinity Chromatography
Synonyms
DNMT1; Polyclonal Antibody; DNMT1 Antibody; Rabbit Polyclonal DNMT1 Antibody; Polyclonal DNMT1 antibody; anti-DNMT1 antibody; DNA methyltransferase HsaI antibody; DNMT-1 antibody; DNMT 1 antibody; MCMT antibody; DNMT 1; DNA (cytosine-5)-methyltransferase 1 antibody; Dnmt1 antibody; DNMT-1; CXXC-type Zinc finger protein 9 antibody; M.HsaI antibody; DNA MTase HsaI antibody
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity Chromatography
Form/Format
Supplied in PBS buffer, pH 7.2, containing 30% Glycerol, 0.5% BSA, 0.01% Thimerosal
Concentration
500 ug/ml (varies by lot)
Sequence Length
1632
Applicable Applications for anti-DNMT1 antibody
Western Blot (WB)
Application Notes
WB: 0.5-4 ug/ml
Immunogen
DNMT1 antibody was raised in Rabbit using synthetic peptide surrounding amino acid 1208 of rat DNMT1 as the immunogen.
Cross-Reactivity
Human, Mouse, Rat
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Western Blot (WB)
(Western blot analysis of DNMT1 with lysate from rat kidney tissue (Lane 1), 3T3 cells (Lane 2) and Jurkat cell lysates (Lane 3 & 4).)
Western Blot (WB)
(Western blot analysis of DNMT1 with lysate from rat kidney tissue (Lane 1), 3T3 cells (Lane 2) and Jurkat cell lysates (Lane 3 & 4).)
Related Product Information for anti-DNMT1 antibody
Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality.
Product Categories/Family for anti-DNMT1 antibody
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Research Articles on DNMT1
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Product Notes
The DNMT1 (Catalog #AAA5311556) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's DNMT1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 0.5-4 ug/ml. Researchers should empirically determine the suitability of the DNMT1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DNMT1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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