Testing Data
Rabbit DNMT1 Polyclonal Antibody | anti-DNMT1 antibody
DNMT1 Antibody
Appearance: Colorless liquid
Shelf Life: 12 months
Testing Data
Testing Data
NCBI and Uniprot Product Information
NCBI Description
methylates genomic DNA; involved in processes of gene inactivation, chromatin organization, X chromosome inactivation and genomic imprinting [RGD, Feb 2006]
Uniprot Description
DNMT1: an ubiquitous DNA methyltransferase that methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development, and may play an active role in DNA damage repair. Mediates transcriptional repression by direct binding to HDAC2. Its abundance is reduced to non detectable levels at the G0 phase of the cell cycle and is dramatically induced upon entrance into the S-phase of the cell cycle. Interacts with HDAC1 and with PCNA. Forms a complex with DMAP1 and HDAC2, with direct interaction. Forms also a stable complex with E2F1, BB1 and HDAC1. Binds MBD2 and MBD3. Three isoforms of the human protein produced by alternative splicing have been described.
Protein type: Amino Acid Metabolism - cysteine and methionine; Transcription regulation; Methyltransferase; Cell development/differentiation; Methyltransferase, DNA; EC 2.1.1.37
Cellular Component: heterochromatin; centric heterochromatin; protein complex; cell soma; cytoplasm; replication fork; nucleus
Molecular Function: methyltransferase activity; protein domain specific binding; methyl-CpG binding; unmethylated CpG binding; zinc ion binding; RNA binding; histone deacetylase binding; S-adenosylmethionine-dependent methyltransferase activity; DNA-methyltransferase activity; transcription factor binding; DNA (cytosine-5-)-methyltransferase activity; protein binding; DNA binding; DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates; double-stranded DNA binding; estrogen receptor binding; chromatin binding
Biological Process: maintenance of DNA methylation; response to toxin; S-adenosylhomocysteine metabolic process; response to lipopolysaccharide; negative regulation of transcription from RNA polymerase II promoter; positive regulation of histone H3-K4 methylation; gene silencing; response to estradiol stimulus; response to caffeine; response to vitamin A; neuron differentiation; response to organic substance; regulation of transcription, DNA-dependent; DNA methylation; DNA methylation on cytosine; aging; response to nutrient levels; response to drug; negative regulation of histone H3-K9 methylation; transcription, DNA-dependent; S-adenosylmethionine metabolic process; response to testosterone stimulus; chromatin modification; regulation of cell proliferation; cytosine methylation within a CG sequence; response to ethanol; response to heat; regulation of gene expression; response to lead ion; S-adenosylmethioninamine metabolic process; response to activity; response to ionizing radiation; brain development; negative regulation of transcription, DNA-dependent
Research Articles on DNMT1
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Product Notes
The DNMT1 dnmt1 (Catalog #AAA840839) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DNMT1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's DNMT1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blot analysis (0.5-4 ug/ml). However, the optimal conditions should be determined individually. Rat kidney tissue lysate can be used as a positive control. Researchers should empirically determine the suitability of the DNMT1 dnmt1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DNMT1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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