Western Blot/Blotting
(Western blot analysis using Disabled-1 (NT) (1) and (CT) (2) on mouse brain extracts.)
Sheep anti-Mouse Disabled Polyclonal Antibody | anti-Dab1 antibody
Disabled (NT)
Western Blot/Blotting
(Western blot analysis using Disabled-1 (NT) (1) and (CT) (2) on mouse brain extracts.)
Western Blot/Blotting
(Western blot analysis using Disabled-1 (NT) (1) and (CT) (2) on mouse brain extracts.)
NCBI and Uniprot Product Information
Uniprot Description
Function: Adapter molecule functioning in neural development. May regulate SIAH1 activity. Ref.1
Subunit structure: Associates with the SH2 domains of SRC, FYN and ABL. Interacts (phosphorylated on tyrosine residues) with CRK and CRKL (via respective SH2 domain). Interacts with DAB2IP, SIAH1, LRP1, LRP8 and VLDLR. Interacts with APLP1 (via NPXY motif). Ref.1 Ref.7 Ref.8 Ref.9 Ref.10
Tissue specificity: Expressed mainly in brain. Ref.1
Domain: The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins.
Post-translational modification: Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons (Ref.5). Also found phosphorylated on Tyr-232 upon reelin induction (Ref.8). Also phosphorylated on Ser-524 independently of reelin signaling. Ref.4 Ref.5 Ref.6 Ref.8
Sequence similarities: Contains 1 PID domain.
Research Articles on Dab1
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Product Notes
The Dab1 dab1 (Catalog #AAA395918) is an Antibody produced from Sheep and is intended for research purposes only. The product is available for immediate purchase. The Disabled (NT) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Disabled can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the Dab1 dab1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Disabled, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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