Western Blot (WB)
(CAPN6 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the CAPN6 antibody detected the CAPN6 protein (arrow).)
Rabbit CAPN6 Polyclonal Antibody | anti-CAPN6 antibody
CAPN6 Antibody (Center)
Western Blot (WB)
(CAPN6 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the CAPN6 antibody detected the CAPN6 protein (arrow).)
Western Blot (WB)
(CAPN6 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the CAPN6 antibody detected the CAPN6 protein (arrow).)
Immunohistochemistry (IHC)
(CAPN6 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CAPN6 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(CAPN6 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CAPN6 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
calcium-dependent, cysteine proteases. The calpain proteins are
heterodimers consisting of an invariant small subunit and variable
large subunits. The large subunit possesses a cysteine protease
domain, and both subunits possess calcium-binding domains. Calpains
have been implicated in neurodegenerative processes, as their
activation can be triggered by calcium influx and oxidative stress.
The protein encoded by this gene is highly expressed in the
placenta. Its C-terminal region lacks any homology to the
calmodulin-like domain of other calpains. The protein lacks
critical active site residues and thus is suggested to be
proteolytically inactive. The protein may play a role in tumor
formation by inhibiting apoptosis and promoting angiogenesis.
Secolin, R., et al. Psychiatr. Genet. 20(3):126-129(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Rho, S.B., et al. Cancer Lett. 271(2):306-313(2008)
Rojas, F.J., et al. Mol. Hum. Reprod. 5(6):520-526(1999)
NCBI and Uniprot Product Information
NCBI Description
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009]
Uniprot Description
CAPN6: Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues. Belongs to the peptidase C2 family.
Chromosomal Location of Human Ortholog: Xq23
Cellular Component: spindle microtubule; perinuclear region of cytoplasm
Molecular Function: microtubule binding; calcium-dependent cysteine-type endopeptidase activity
Biological Process: proteolysis; microtubule bundle formation; regulation of cytoskeleton organization and biogenesis
Research Articles on CAPN6
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Product Notes
The CAPN6 capn6 (Catalog #AAA9212784) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 390-419. The CAPN6 Antibody (Center) reacts with Human (Predicted Reactivity: Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's CAPN6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the CAPN6 capn6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CAPN6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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