Rabbit Dipeptidylpeptidase 8 / DPP8 Polyclonal Antibody | anti-DPP8 antibody

Rabbit Polyclonal to Human Dipeptidylpeptidase 8 / DPP8

Cat. Num. AAA240135

• Gene Names: DPP8; DP8; DPRP1; MSTP141
• Reactivity: Gibbon, Gorilla, Human, Monkey, Rabbit; Predicted Reactivity: Bat, Bovine, Dog, Horse, Pig (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: Dipeptidylpeptidase 8 / DPP8; Polyclonal Antibody; Rabbit Polyclonal to Human Dipeptidylpeptidase 8 / DPP8; Anti-Dipeptidylpeptidase 8 / DPP8 Antibody (Internal) IHC-plus; DPP8; Dipeptidyl-peptidase 8; DPRP1; Dipeptidyl peptidase VIII; Dipeptidylpeptidase 8; DPRP-1; Dipeptidyl peptidase 8; MSTP141; Prolyl dipeptidase DPP8; DP8; DPP VIII; Human Dipeptidylpeptidase 8; anti-DPP8 antibody

• Host: Rabbit
• Reactivity: Gibbon, Gorilla, Human, Monkey, Rabbit; Predicted Reactivity: Bat, Bovine, Dog, Horse, Pig (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human DPP8. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except DPP9 (61%).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 0.8 mg/ml (varies by lot)
• Sequence Length: 882

• Applicable Applications for anti-DPP8 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (20 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: Synthetic 18 amino acid peptide from internal region of human DPP8 (NP_569118.1). Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Rabbit (100%); Dog, Bovine, Bat, Panda, Horse, Pig (94%).
• Immunogen: Dipeptidylpeptidase 8 / DPP8 antibody was raised against synthetic 18 amino acid peptide from internal region of human DPP8 (NP_569118.1). Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Rabbit (100%); Dog, Bovine, Bat, Panda, Horse, Pig (94%); Marmoset, Elephant, Opossum (89%); Mouse, Rat (83%).
• Antigen Modification: Internal
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-DPP8 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Product Categories/Family for anti-DPP8 antibody

Family: Protease; Subfamily: Serine S9B

NCBI and Uniprot Product Information

• NCBI GI #: 18450280
• NCBI GeneID: 54878
• NCBI Accession #: NP_569118.1
• NCBI GenBank Nucleotide #: NM_130434.3
• UniProt Accession #: Q6V1X1; Q7Z4C8; Q7Z4D3; Q7Z4E1; Q8IWG7; Q8NEM5; Q96JX1; Q9HBM2; Q9HBM3; Q9HBM4; Q9HBM5; Q9NXF4
• Molecular Weight: 83,398 Da
• NCBI Official Full Name: dipeptidyl peptidase 8 isoform 1
• NCBI Official Synonym Full Names: dipeptidyl-peptidase 8
• NCBI Official Symbol: DPP8
• NCBI Official Synonym Symbols: DP8; DPRP1; MSTP141
• NCBI Protein Information: dipeptidyl peptidase 8; DPRP-1; DPP VIII; dipeptidylpeptidase 8; prolyl dipeptidase DPP8; dipeptidyl peptidase VIII; dipeptidyl peptidase IV-related protein 1; dipeptidyl peptidase IV-related protein-1
• UniProt Protein Name: Dipeptidyl peptidase 8
• Protein Family: Dipeptidyl peptidase
• UniProt Gene Name: DPP8
• UniProt Synonym Gene Names: DPRP1; DP8; DPRP-1; DPP VIII
• UniProt Entry Name: DPP8_HUMAN

NCBI Description

This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

DPP8: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function. Belongs to the peptidase S9B family. DPPIV subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.14.5; Protease

Chromosomal Location of Human Ortholog: 15q22

Cellular Component: nucleoplasm; membrane; cytoplasm

Molecular Function: serine-type peptidase activity; dipeptidyl-peptidase activity

Biological Process: immune response; proteolysis