Related Product Information for anti-DHX36 antibody
This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
Product Categories/Family for anti-DHX36 antibody
References
Lattmann, S., et al. Nucleic Acids Res. 38(18):6219-6233(2010). Kim, T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(34):15181-15186(2010). Chalupnikova, K., et al. J. Biol. Chem. 283(50):35186-35198(2008). Creacy, S.D., et al. J. Biol. Chem. 283(50):34626-34634(2008). Iwamoto, F., et al. Exp. Cell Res. 314(6):1378-1391(2008).
NCBI Description
This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
DHX36: Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. Belongs to the DEAD box helicase family. DEAH subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.6.4.13; EC 3.6.4.12; Helicase; RNA-binding
Chromosomal Location of Human Ortholog: 3q25.2
Cellular Component: chromosome, telomeric region; cytoplasm; cytosol; nucleus
Molecular Function: G-quadruplex DNA binding; DNA-dependent ATPase activity; protein binding; histone deacetylase binding; double-stranded RNA binding; ATP-dependent RNA helicase activity; ATP binding
Biological Process: RNA processing; ossification; response to exogenous dsRNA; transcription, DNA-dependent; response to virus; RNA secondary structure unwinding; positive regulation of telomere maintenance; positive regulation of interferon type I production; innate immune response; positive regulation of transcription from RNA polymerase II promoter
Product Notes
The DHX36 dhx36 (Catalog #
AAA6292119) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DHX36, ID (DHX36, DDX36, KIAA1488, MLEL1, RHAU, Probable ATP-dependent RNA helicase DHX36, DEAH box protein 36, MLE-like protein 1, RNA helicase associated with AU-rich element ARE) (MaxLight 490) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DHX36 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), FLISA. WB: 1:100-500 FLISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the DHX36 dhx36 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"DHX36, Polyclonal Antibody" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
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absolutely not suitable for use in any
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and its authorized distribution partners reserve the right to refuse to fulfill any order if
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purchaser may be intending to use a product outside of our accepted criteria.
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