Western Blot (WB)
(Western blot analysis of anti-DHCR24 Antibody (N-term) in HepG2 cell line lysates (35ug/lane). DHCR24 (arrow) was detected using the purified Pab.)
Rabbit DHCR24 Polyclonal Antibody | anti-DHCR24 antibody
DHCR24 Antibody (N-term)
Western Blot (WB)
(Western blot analysis of anti-DHCR24 Antibody (N-term) in HepG2 cell line lysates (35ug/lane). DHCR24 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of anti-DHCR24 Antibody (N-term) in HepG2 cell line lysates (35ug/lane). DHCR24 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of anti-DHCR24 Antibody (N-term) in mouse liver tissue lysates (35ug/lane). DHCR24 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of anti-DHCR24 Antibody (N-term) in mouse liver tissue lysates (35ug/lane). DHCR24 (arrow) was detected using the purified Pab.)
Bonaccorsi,L., Lab. Invest. 88 (10), 1049-1056 (2008)
Cecchi,C., J. Cell. Mol. Med. 12 (5B), 1990-2002 (2008)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]
Uniprot Description
Diminuto: the enzyme 3-beta-hydroxysterol delta-24-reductase (DHCR24), a member of the flavin adenine dinucleotide (FAD)-dependent oxidoreductases, catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. Overexpressed in the adenoma tissue of patients with Cushing's syndrome. May be involved in the molecular events of adrenocortical tumorigenesis by facilitating steroid synthesis and cell growth.
Protein type: EC 1.3.1.72; Oxidoreductase; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p32.3
Cellular Component: Golgi membrane; endoplasmic reticulum membrane; cytoskeleton; membrane; endoplasmic reticulum; integral to membrane; cytosol; nucleus
Molecular Function: delta24(24-1) sterol reductase activity; UDP-N-acetylmuramate dehydrogenase activity; enzyme binding; FAD binding; peptide antigen binding; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; delta24-sterol reductase activity
Biological Process: skin development; tissue development; apoptosis; response to hormone stimulus; negative regulation of caspase activity; cholesterol biosynthetic process; negative regulation of cell proliferation; protein localization; amyloid precursor protein catabolic process; Ras protein signal transduction; male genitalia development; response to oxidative stress; cell cycle arrest; plasminogen activation; negative regulation of apoptosis
Disease: Desmosterolosis
Research Articles on DHCR24
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Product Notes
The DHCR24 dhcr24 (Catalog #AAA9213592) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 57-87. The DHCR24 Antibody (N-term) reacts with Human, mouse (Predicted Reactivity: Monkey) and may cross-react with other species as described in the data sheet. AAA Biotech's DHCR24 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the DHCR24 dhcr24 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DHCR24, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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