Rabbit Desmoglein 4 Polyclonal Antibody | anti-DSG4 antibody

Desmoglein 4 Polyclonal Antibody

Cat. Num. AAA3006409

• Gene Names: DSG4; LAH; HYPT6; CDGF13; CDHF13
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: Desmoglein 4; Polyclonal Antibody; Desmoglein 4 Polyclonal Antibody; Desmoglein-4; Desmoglein4; Cadherin family member 13; DSG4; CDHF13; anti-DSG4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Desmoglein 4 polyclonal antibody detects endogenous levels of Desmoglein 4 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 1040

• Applicable Applications for anti-DSG4 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human Desmoglein 4.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of Desmoglein 4 polyclonal antibody at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:sp2/0 whole cell lysateLane3:H9C2 whole cell lysate)

Related Product Information for anti-DSG4 antibody

Desmoglein proteins are cadherin-type cell adhesion molecules. Desmoglein 4 (dsg4) shares 41% identity with human desmoglein 1, 37% with human desmoglein 2 and 50% with human desmoglein 3. A type I membrane protein of the cadherin protein family, dsg4 is expressed in salivary gland, suprabasal epidermis, hair follicle, testis, prostate and skin. In the hair follicle, dsg4 is an important mediator of keratinocyte cell adhesion and coordinates the transition from proliferation to differentiation. The human DSG4 gene is composed of 16 exons spanning approximately 37 kb of 18q12 and is situated between DSG1 and DSG3.

NCBI and Uniprot Product Information

• NCBI GI #: 29789445
• NCBI GeneID: 147409
• NCBI Accession #: NP_817123.1
• NCBI GenBank Nucleotide #: NP_817123.1
• UniProt Accession #: Q86SJ6
• Molecular Weight: ~ 114kDa
• NCBI Official Full Name: desmoglein-4 isoform 2 preproprotein
• NCBI Official Synonym Full Names: desmoglein 4
• NCBI Official Symbol: DSG4
• NCBI Official Synonym Symbols: LAH; HYPT6; CDGF13; CDHF13
• NCBI Protein Information: desmoglein-4
• UniProt Protein Name: Desmoglein-4
• Protein Family: Desmoglein
• UniProt Gene Name: DSG4
• UniProt Synonym Gene Names: CDHF13

NCBI Description

This gene encodes a member of the desmoglein subgroup of desmosomal cadherins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a transmembrane component of desmosomes and may play a role in cell-cell adhesion in epithelial cells. Mutations in the gene are associated with localized autosomal recessive hypotrichosis and monilethrix, characterized by impaired hair growth. [provided by RefSeq, May 2016]

Uniprot Description

DSG4: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. Defects in DSG4 are the cause of hypotrichosis type 6 (HYPT6). A condition characterized by the presence of less than the normal amount of hair, involving mainly the scalp, chest, arms and legs. It is characterized by abnormal hair follicles and shafts, which are thin and atrophic. Autoantibodies against DSG4 are found in patients with pemphigus vulgaris. Pemphigus vulgaris is a potentially lethal skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q12.1

Disease: Hypotrichosis 6