Rabbit anti-Human DEFA5 Polyclonal Antibody | anti-DEFA5 antibody

DEFA5 (Defensin-5, Defensin, alpha 5, HD5(20-94), DEF5) (MaxLight 490)

Cat. Num. AAA6375991

• Gene Names: DEFA5; DEF5; HD-5
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: DEFA5; Polyclonal Antibody; DEFA5 (Defensin-5; Defensin; alpha 5; HD5(20-94); DEF5) (MaxLight 490); anti-DEFA5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human DEFA5.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.

• Applicable Applications for anti-DEFA5 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length recombinant protein corresponding to aa1-94 from human DEFA5.
• Immunogen Sequence: MRTIAILAAILLVALQAQAESLQERADEATTQKQSGEDNQDLAISFAGNGLSALRTSGSQARATCYCRTGRCATRESLSGVCEISGRLYRLCCR
• Conjugate: MaxLight490
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of DEFA5 expression in transfected 293T cell line usingMBS644032. Lane 1: DEFA5 transfected lysate (10.1kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-DEFA5 antibody

Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.

Product Categories/Family for anti-DEFA5 antibody

Antibodies; Defensin

NCBI and Uniprot Product Information

• NCBI GI #: 10337585
• NCBI GeneID: 1670
• NCBI Accession #: NP_066290.1
• NCBI GenBank Nucleotide #: NM_021010.1
• UniProt Accession #: Q01523; Q3KNV2; A0JDY6
• Molecular Weight: 10,071 Da
• NCBI Official Full Name: defensin-5 preproprotein
• NCBI Official Synonym Full Names: defensin, alpha 5, Paneth cell-specific
• NCBI Official Symbol: DEFA5
• NCBI Official Synonym Symbols: DEF5; HD-5
• NCBI Protein Information: defensin-5; HD5(20-94); defensin 5; defensin, alpha 5, preproprotein
• UniProt Protein Name: Defensin-5
• Protein Family: Defensin
• UniProt Gene Name: DEFA5
• UniProt Synonym Gene Names: DEF5
• UniProt Entry Name: DEF5_HUMAN

NCBI Description

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. [provided by RefSeq, Jul 2008]

Uniprot Description

DEFA5: Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing. Belongs to the alpha-defensin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: extracellular space; transport vesicle; Golgi lumen; extracellular region

Biological Process: killing of cells of another organism; antibacterial humoral response; innate immune response; defense response to fungus