Rabbit Dectin-1 Polyclonal Antibody | anti-Clec7a antibody

Dectin-1 (C-type lectin domain family 7 member A, Dendritic cell-associated C-type lectin 1, DC-associated C-type lectin 1, Beta-glucan receptor, C-type lectin superfamily member 12, CLEC7A, BGR, CLECSF12, DECTIN1, UNQ539/PRO1082)

Cat. Num. AAA621017

• Gene Names: Clec7a; BGR; beta-GR; Clecsf12
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purified; Purified by affinitiy chromatography.
• Synonyms: Dectin-1; Polyclonal Antibody; Dectin-1 (C-type lectin domain family 7 member A; Dendritic cell-associated C-type lectin 1; DC-associated C-type lectin 1; Beta-glucan receptor; C-type lectin superfamily member 12; CLEC7A; BGR; CLECSF12; DECTIN1; UNQ539/PRO1082); Anti -Dectin-1 (C-type lectin domain family 7 member A; anti-Clec7a antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Dectin-1 at ~28kD. A ~16kD monomeric form and a 43kD glycoprotein can also be detected.
• Purity/Purification: Affinity Purified; Purified by affinitiy chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.5% BSA, 0.01% thimerosal, 30% glycerol.

• Applicable Applications for anti-Clec7a antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot: 0.5-4ug/ml
• Immunogen: Synthetic peptide surrounding aa161 of human Dectin-1.
• Molecular Formula: Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: ~0.5mg/ml Form: Supplied as a liquid in PBS, pH 7.2, 0.5% BSA, 0.01% thimerosal, 30% glycerol. Purity: Purified by affinitiy chromatography. Immunogen: Synthetic peptide corresponding to aa1161 of human Dectin-1. Specificity: Recognizes human Dectin-1 at ~28kD. A ~16kD monomeric form and a 43kD glycoprotein can also be detected. Species Crossreactivity: mouse, rat. Important Note: This product as supplied is intended for research use only, not for use in human applications without the expressed written authorization of MyBioSource.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of Dectin-1 expresssion using MBS621017. Lane 1: rat kidney Lane 2: 3T3 cells lysate Lane 3: Jurkat cells lysate Lane 4: Jurkat cells lysate)

Related Product Information for anti-Clec7a antibody

Dectin-1also known as beta-glucan receptor is a small type II transmembrane receptor containing lectin-like carbohydrate recognition domain. Dectin-1 plays a role in beta-glucan dependant, nonopsonic recognition of zymosan by primary macropahge. Dectin-1 is expressed on macrophages and neutrophils and on some dendritic cells subpopulation.

Product Categories/Family for anti-Clec7a antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 8102031
• NCBI GeneID: 56644
• UniProt Accession #: Q6QLQ4; Q8K1L4; Q9JI50; E9QPW2
• Molecular Weight: 27,420 Da
• NCBI Official Full Name: dendritic cell-associated C-type lectin-1
• NCBI Official Synonym Full Names: C-type lectin domain family 7, member a
• NCBI Official Symbol: Clec7a
• NCBI Official Synonym Symbols: BGR; beta-GR; Clecsf12
• NCBI Protein Information: C-type lectin domain family 7 member A; dectin-1; beta-glucan receptor; DC-associated C-type lectin 1; C-type lectin superfamily member 12; dendritic cell-associated C-type lectin 1; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12
• UniProt Protein Name: C-type lectin domain family 7 member A
• Protein Family: C-type lectin domain family
• UniProt Gene Name: Clec7a
• UniProt Synonym Gene Names: Bgr; Clecsf12; Dectin1; DC-associated C-type lectin 1; Dectin-1
• UniProt Entry Name: CLC7A_MOUSE

Uniprot Description

dectin-1: Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Up-regulated during differentiation from monocytes into dendritic cells. Isoform 5 interacts with RANBP9. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: membrane; integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function: zymosan receptor activity; opsonin binding; protein binding; metal ion binding; zymosan binding; carbohydrate binding; pattern recognition receptor activity; polysaccharide binding

Biological Process: immune system process; cell surface pattern recognition receptor signaling pathway; phagocytosis, recognition; cell recognition; pattern recognition receptor signaling pathway; response to molecule of fungal origin; positive regulation of tumor necrosis factor production; cell-cell adhesion; leukocyte activation during immune response; positive regulation of phagocytosis; innate immune response; response to yeast; detection of yeast; inflammatory response; phagocytosis, engulfment