Rabbit anti-Human, Mouse DDX58 Polyclonal Antibody | anti-DDX58 antibody
DDX58 (Phospho-Thr170) Antibody HRP Conjugated
Gene Names
DDX58; RIGI; RIG-I; RLR-1
Reactivity
Human, Mouse
Applications
Western Blot, Immunohistochemistry
Purity
Purified by Protein A
Synonyms
DDX58; Polyclonal Antibody; DDX58 (Phospho-Thr170) Antibody HRP Conjugated; DEAD H Asp-Glu-Ala-Asp His box polypeptide RIG-I; DKFZp434J1111; DKFZp686N19181; FLJ13599; C330021E21; OTTHUMP00000045225; DEAD Asp-Glu-Ala-Asp box polypeptide 58; DEAD Asp Glu Ala Asp His box polypeptide; DEAD box protein 58; Probable ATP dependent RNA helicase DDX58; Retinoic acid inducible gene 1; DDX58 Thr170; anti-DDX58 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Purified by Protein A
Form/Format
10mM Tris Buffered Saline containing 1% BSA, 50% glycerol and 0.09% Gentamicin.
Concentration
1mgml (varies by lot)
Applicable Applications for anti-DDX58 antibody
Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
Application Notes
WB: 1:100-1000
IHC: 1:100-500
IHC: 1:100-500
Conjugation
HRP
Immunogen
KLH conjugated synthetic phosphopeptide derived from human DDX58 around the phosphorylation site of Thr170
Preparation and Storage
Store at 4 degree C for 12 months.
Related Product Information for anti-DDX58 antibody
The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the cytoplasmic helicase retinoic acid inducible gene protein 1 (RIG1 DDX58) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. Unlike TLR3 however, RIG1 DDX58 activates the kinases TBK1 and IKKe through the adaptor protein IPS1. These kinases then phosphorylate the transcription factors IRF3 and IRF7 which are essential for the expression of type-I interferons. RIG1 DDX58 is required for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus.
Product Categories/Family for anti-DDX58 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
925
NCBI Official Full Name
probable ATP-dependent RNA helicase DDX58
NCBI Official Synonym Full Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
NCBI Official Symbol
DDX58
NCBI Official Synonym Symbols
RIGI; RIG-I; RLR-1
NCBI Protein Information
probable ATP-dependent RNA helicase DDX58; RIG-1; RNA helicase RIG-I; DEAD box protein 58; RIG-I-like receptor 1; retinoic acid inducible gene I; retinoic acid-inducible gene 1 protein; retinoic acid-inducible gene I protein; DEAD/H (Asp-Glu-Ala-Asp/His)
UniProt Protein Name
Probable ATP-dependent RNA helicase DDX58
Protein Family
UniProt Gene Name
DDX58
UniProt Synonym Gene Names
RLR-1; RIG-1; RIG-I
UniProt Entry Name
DDX58_HUMAN
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Product Notes
The DDX58 ddx58 (Catalog #AAA9461590) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DDX58 (Phospho-Thr170) Antibody HRP Conjugated reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's DDX58 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P). WB: 1:100-1000 IHC: 1:100-500. Researchers should empirically determine the suitability of the DDX58 ddx58 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DDX58, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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