Rabbit anti-Human DDIT4L Polyclonal Antibody | anti-DDIT4L antibody

DDIT4L, NT (DDIT4L, REDD2, RTP801L, DNA damage-inducible transcript 4-like protein, HIF-1 responsive protein RTP801-like, Protein regulated in development and DNA damage response 2) (PE)

Cat. Num. AAA6291309

• Gene Names: DDIT4L; REDD2; Rtp801L
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: DDIT4L; Polyclonal Antibody; NT (DDIT4L; REDD2; RTP801L; DNA damage-inducible transcript 4-like protein; HIF-1 responsive protein RTP801-like; Protein regulated in development and DNA damage response 2) (PE); Protein regulated in development and DNA damage response 2; anti-DDIT4L antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-DDIT4L antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: DDIT4L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-34 amino acids from the N-terminal region of human DDIT4L.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(DDIT4L Antibody (N-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the DDIT4L antibody detected the DDIT4L protein (arrow).)

Related Product Information for anti-DDIT4L antibody

DDIT4L inhibits cell growth by regulating the FRAP1 pathway upstream of the TSC1-TSC2 complex and downstream of AKT1.

Product Categories/Family for anti-DDIT4L antibody

Antibodies; Proteins

References

Koga, Y., et al. Genome Res. 19(8):1462-1470(2009). Imen, J.S., et al. Free Radic. Biol. Med. 46(10):1404-1410(2009). Lamesch, P., et al. Genomics 89(3):307-315(2007). Corradetti, M.N., et al. J. Biol. Chem. 280(11):9769-9772(2005). Cuaz-Perolin, C., et al. Arterioscler. Thromb. Vasc. Biol. 24(10):1830-1835(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 21687001
• NCBI GeneID: 115265
• NCBI Accession #: NP_660287.1
• NCBI GenBank Nucleotide #: NM_145244.3
• UniProt Accession #: Q96D03; B2R7C3
• Molecular Weight: 21,740 Da
• NCBI Official Full Name: DNA damage-inducible transcript 4-like protein
• NCBI Official Synonym Full Names: DNA-damage-inducible transcript 4-like
• NCBI Official Symbol: DDIT4L
• NCBI Official Synonym Symbols: REDD2; Rtp801L
• NCBI Protein Information: DNA damage-inducible transcript 4-like protein; REDD-2; homolog of mouse SMHS1; HIF-1 responsive protein RTP801-like; regulated in development and DNA damage response 2; protein regulated in development and DNA damage response 2
• UniProt Protein Name: DNA damage-inducible transcript 4-like protein
• Protein Family: DNA damage-inducible transcript 4-like protein
• UniProt Gene Name: DDIT4L
• UniProt Synonym Gene Names: REDD2; RTP801L; REDD-2
• UniProt Entry Name: DDT4L_HUMAN

Uniprot Description

DDIT4L: Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Belongs to the DDIT4 family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: cytoplasm

Biological Process: negative regulation of signal transduction