Mouse Tumor necrosis factor receptor superfamily member EDAR ELISA Kit | Edar elisa kit

Mouse Tumor necrosis factor receptor superfamily member EDAR ELISA Kit

Cat. Num. AAA2888090

• Gene Names: EDAR; DL; ED3; ED5; ED1R; EDA3; HRM1; EDA1R; ECTD10A; ECTD10B; EDA-A1R
• Reactivity: Mouse
• Synonyms: Tumor necrosis factor receptor superfamily member EDAR; Mouse Tumor necrosis factor receptor superfamily member EDAR ELISA Kit; Anhidrotic ectodysplasin receptor 1; Downless; Ectodermal dysplasia receptor; Ectodysplasin-A receptor; Edar; Dl; Edar elisa kit

• Reactivity: Mouse
• Sequence Length: 448

• Assay Type: Sandwich
• Detection Range: 78-5000 pg/mL
• Sensitivity: 39.7 pg/mL
• Intra-Assay CV: <=7.2%
• Inter-Assay CV: <=9.5%
• Recovery: 90%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 11641231
• NCBI GeneID: 10913
• NCBI Accession #: NP_071731.1
• NCBI GenBank Nucleotide #: NM_022336.3
• Molecular Weight: 51,690 Da
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member EDAR
• NCBI Official Synonym Full Names: ectodysplasin A receptor
• NCBI Official Symbol: EDAR
• NCBI Official Synonym Symbols: DL; ED3; ED5; ED1R; EDA3; HRM1; EDA1R; ECTD10A; ECTD10B; EDA-A1R
• NCBI Protein Information: tumor necrosis factor receptor superfamily member EDAR
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member EDAR
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: EDAR
• UniProt Synonym Gene Names: DL
• UniProt Entry Name: EDAR_HUMAN

NCBI Description

This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia. [provided by RefSeq, Jul 2008]

Uniprot Description

EDAR: Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death. Defects in EDAR are a cause of ectodermal dysplasia anhidrotic (EDA); also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. Defects in EDAR are the cause of ectodermal dysplasia type 3 (ED3); also known as ectodermal dysplasia hypohidrotic autosomal dominant or EDA3. ED3 is an autosomal dominant condition characterized by hypotrichosis, abnormal or missing teeth, and hypohidrosis due to the absence of sweat glands.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 2q13

Cellular Component: plasma membrane

Molecular Function: protein binding; receptor activity

Biological Process: epidermis development; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; tumor necrosis factor-mediated signaling pathway

Disease: Ectodermal Dysplasia 10a, Hypohidrotic/hair/nail Type, Autosomal Dominant; Ectodermal Dysplasia 10b, Hypohidrotic/hair/tooth Type, Autosomal Recessive; Hair Morphology 1