Western Blot (WB)
(DCTD Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the DCTD antibody detected the DCTD protein (arrow).)
Rabbit DCTD Polyclonal Antibody | anti-DCTD antibody
DCTD Antibody (N-term)
Western Blot (WB)
(DCTD Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the DCTD antibody detected the DCTD protein (arrow).)
Western Blot (WB)
(DCTD Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the DCTD antibody detected the DCTD protein (arrow).)
Western Blot (WB)
(Western blot analysis of DCTD (arrow) using rabbit polyclonal DCTD Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the DCTD gene.)
Western Blot (WB)
(Western blot analysis of DCTD (arrow) using rabbit polyclonal DCTD Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the DCTD gene.)
of dCMP to dUMP, the nucleotide substrate for thymidylate synthase.
The encoded protein is allosterically activated by dCTP and
inhibited by dTTP, and is found as a homohexamer. This protein uses
zinc as a cofactor for its activity. Two transcript variants
encoding different isoforms have been found for this gene.
Okazaki, T., et al. Clin. Cancer Res. 16(1):320-329(2010)
Rha, S.Y., et al. Oncologist 12(6):622-630(2007)
Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
DCTD: catalyzes the deamination of dCMP to dUMP, thus providing the nucleotide substrate for thymidylate synthase. Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP.
Protein type: Hydrolase; Nucleotide Metabolism - pyrimidine; EC 3.5.4.12
Chromosomal Location of Human Ortholog: 4q35.1
Cellular Component: cytosol
Molecular Function: zinc ion binding; dCMP deaminase activity
Biological Process: pyrimidine base metabolic process; pyrimidine nucleotide metabolic process; nucleobase, nucleoside and nucleotide metabolic process; nucleotide biosynthetic process; pyrimidine nucleoside biosynthetic process
Research Articles on DCTD
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Product Notes
The DCTD dctd (Catalog #AAA9212376) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-30. The DCTD Antibody (N-term) reacts with Human (Predicted Reactivity: Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's DCTD can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the DCTD dctd for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DCTD, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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