Rabbit anti-Human DCD Polyclonal Antibody | anti-DCD antibody

DCD Polyclonal Antibody

Cat. Num. AAA2562484

• Gene Names: DCD; PIF; AIDD; DSEP; HCAP; DCD-1
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: DCD; Polyclonal Antibody; DCD Polyclonal Antibody; AIDD; DCD 1; Dcd; DCD-1; DSEP; HCAP; PIF; Preproteolysin; anti-DCD antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 0.66mg/mL (varies by lot)
• Sequence Length: 110

• Applicable Applications for anti-DCD antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:30-1:150; ELISA: 1:5000-1:10000
• Immunogen: Fusion protein of human DCD
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using DCD Polyclonal Antibody at dilution of 1:35(×200))

Related Product Information for anti-DCD antibody

This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms.

Product Categories/Family for anti-DCD antibody

Cell Biology; Metabolism; Microbiology

NCBI and Uniprot Product Information

• NCBI GI #: 16751921
• NCBI GeneID: 117159
• NCBI Accession #: NP_444513.1; BC062682
• NCBI GenBank Nucleotide #: NP_444513.1
• UniProt Accession #: P81605
• NCBI Official Full Name: dermcidin isoform 1 preproprotein
• NCBI Official Synonym Full Names: dermcidin
• NCBI Official Symbol: DCD
• NCBI Official Synonym Symbols: PIF; AIDD; DSEP; HCAP; DCD-1
• NCBI Protein Information: dermcidin
• UniProt Protein Name: Dermcidin
• Protein Family: Dermcidin
• UniProt Gene Name: DCD
• UniProt Synonym Gene Names: AIDD; DSEP
• UniProt Entry Name: DCD_HUMAN

NCBI Description

This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Uniprot Description

DCD: DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; EC 3.4.-.-

Chromosomal Location of Human Ortholog: 12q13.1

Cellular Component: extracellular region

Molecular Function: peptidase activity

Biological Process: killing of cells of another organism; defense response to bacterium; proteolysis; defense response to fungus