Rabbit anti-Human DAZ1 Polyclonal Antibody | anti-DAZ1 antibody

DAZ1 Polyclonal Antibody

Cat. Num. AAA2562472

• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: DAZ1; Polyclonal Antibody; DAZ1 Polyclonal Antibody; Deleted In Azoospermia Protein 1; SPGY; DAZ; Testicular Tissue Protein Li 49; anti-DAZ1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 1.38mg/mL (varies by lot)
• Sequence Length: 744

• Applicable Applications for anti-DAZ1 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:50-1:300; ELISA: 1:5000-1:10000
• Immunogen: Fusion protein of human DAZ1
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using DAZ1 Polyclonal Antibody at dilution of 1:70(×200))

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using DAZ1 Polyclonal Antibody at dilution of 1:70(×200))

Related Product Information for anti-DAZ1 antibody

This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains three copies of the 10.8 kb repeat. However, no transcripts containing three copies of the RRM domain have been described; thus the RefSeq for this gene contains only two RRM domains.

Product Categories/Family for anti-DAZ1 antibody

Epigenetics and Nuclear Signaling; Stem Cells

NCBI and Uniprot Product Information

• NCBI GI #: 189181654
• NCBI Accession #: NP_004072.3; BC114927
• NCBI GenBank Nucleotide #: NP_004072.3
• UniProt Accession #: Q9NQZ3
• NCBI Official Full Name: deleted in azoospermia protein 1
• UniProt Protein Name: Deleted in azoospermia protein 1
• Protein Family: Deleted in azoospermia protein
• UniProt Gene Name: DAZ1
• UniProt Synonym Gene Names: DAZ; SPGY
• UniProt Entry Name: DAZ1_HUMAN

Uniprot Description

DAZ1: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells. Defects in DAZ1 may be a cause of spermatogenic failure Y-linked type 2 (SPGFY2). It is a disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. AZFc deletions in the Yq11.23 region including the DAZ genes are the most common known genetic cause of human male infertility. Belongs to the RRM DAZ family.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: Yq11.223

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; translation activator activity; RNA binding; nucleotide binding

Biological Process: positive regulation of translational initiation; multicellular organismal development; spermatogenesis; cell differentiation

Disease: Spermatogenic Failure, Y-linked, 2