Western Blot (WB)
(Expression analysis of Dapper homolog 1. Anti-Dapper homolog 1 antibody (11-10012) was used at 4 µg/ml on (1) Jurkat lysates.)
Rabbit Dapper homolog 1 Polyclonal Antibody | anti-DACT1 antibody
Dapper homolog 1 Polyclonal Antibody
Western Blot (WB)
(Expression analysis of Dapper homolog 1. Anti-Dapper homolog 1 antibody (11-10012) was used at 4 µg/ml on (1) Jurkat lysates.)
Western Blot (WB)
(Expression analysis of Dapper homolog 1. Anti-Dapper homolog 1 antibody (11-10012) was used at 4 µg/ml on (1) Jurkat lysates.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Description
DACT1: Positively regulates DVL2-mediated signaling pathways during development. Binds to DVL2 and impedes the degradation of CTNNB1/beta-catenin, thereby enhancing the transcriptional activation of target genes of the Wnt signaling pathway. Interacts with DVL1 and DVL2. Belongs to the dapper family.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 14q23.1
Cellular Component: nucleoplasm; cytoplasm; synapse; cytosol; cell junction; beta-catenin destruction complex
Molecular Function: protein binding; protein kinase C binding; protein kinase A binding; beta-catenin binding
Biological Process: negative regulation of JNK cascade; Wnt receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; dendrite morphogenesis; synapse organization and biogenesis; positive regulation of protein catabolic process; positive regulation of fat cell differentiation; regulation of protein stability; negative regulation of transcription from RNA polymerase II promoter; gastrulation with mouth forming second; positive regulation of Wnt receptor signaling pathway; embryonic hindgut morphogenesis
Research Articles on DACT1
Similar Products
Product Notes
The DACT1 dact1 (Catalog #AAA668060) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Dapper homolog 1 Polyclonal Antibody reacts with Human (Predicted Reactivity: Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Dapper homolog 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 2-4 µg/ml. Researchers should empirically determine the suitability of the DACT1 dact1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Dapper homolog 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
