Rabbit DANRE stk3 (36kDa subunit) Polyclonal Antibody | anti-stk3 antibody

DANRE stk3 (36kDa subunit) Antibody (Center)

Cat. Num. AAA9209740

• Gene Names: stk3; zgc:55383; wu:fc19e11
• Reactivity: Human, Zebrafish
• Applications: Western Blot, ELISA
• Purity: Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: DANRE stk3 (36kDa subunit); Polyclonal Antibody; DANRE stk3 (36kDa subunit) Antibody (Center); Serine/threonine-protein kinase 3; Serine/threonine-protein kinase 3 36kDa subunit; MST2/N; Serine/threonine-protein kinase 3 20kDa subunit; MST2/C; stk3; anti-stk3 antibody

• Host: Rabbit
• Reactivity: Human, Zebrafish
• Clonality: Polyclonal
• Specificity: This DANRE stk3(36kDa subunit) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 228-252 amino acids from the Central region of DANRE stk3(36kDa subunit).
• Purity/Purification: Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: Vial Concentration: 0.5 (varies by lot)
• Sequence Length: 492

• Applicable Applications for anti-stk3 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB~~1:1000
• Crown Antibody: Yes
• Antigen Source: Zebrafish
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Western blot analysis of lysates from huaman placenta and zebra fish brain tissue (from left to right),using Zebrafishstk3(36kDa subunit) Antibody (Center). MBS9209740 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.)

Related Product Information for anti-stk3 antibody

Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regulatory protein mob1, which in turn phosphorylates and inactivates yap1 oncoprotein and wwtr1/taz. Phosphorylation of yap1 by lats2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (By similarity).

Product Categories/Family for anti-stk3 antibody

Crown Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 41054445
• NCBI GeneID: 324125
• NCBI Accession #: NP_955966.1
• NCBI GenBank Nucleotide #: NM_199672.1
• UniProt Accession #: Q7ZUQ3
• Molecular Weight: 56081
• NCBI Official Full Name: serine/threonine-protein kinase 3
• NCBI Official Synonym Full Names: serine/threonine kinase 3 (STE20 homolog, yeast)
• NCBI Official Symbol: stk3
• NCBI Official Synonym Symbols: zgc:55383; wu:fc19e11
• NCBI Protein Information: serine/threonine-protein kinase 3
• UniProt Protein Name: Serine/threonine-protein kinase 3
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: stk3
• UniProt Synonym Gene Names: MST2/N; MST2/C
• UniProt Entry Name: STK3_DANRE

Uniprot Description

Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regulatory protein mob1, which in turn phosphorylates and inactivates yap1 oncoprotein and wwtr1/taz. Phosphorylation of yap1 by lats2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration ().