Rabbit anti-Human DAND5 Polyclonal Antibody | anti-DAND5 antibody

DAND5 Polyclonal Antibody

Cat. Num. AAA2562195

• Gene Names: DAND5; SP1; CER2; COCO; CRL2; CERL2; DANTE; GREM3; CKTSF1B3
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: DAND5; Polyclonal Antibody; DAND5 Polyclonal Antibody; BMP antagonist 3; CER2; Cerberus 2; Cerberus like 2; Cerberus-like protein 2; Cerl-2; CERL2; CKTSF1B3; COCO; CRL2; Cysteine knot superfamily 1; Cysteine knot superfamily 1 BMP antagonist 3; DAN domain family member 5; Dand5; DANTE; GREM3; Gremlin-3; MGC126849; SP1; anti-DAND5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 0.9mg/mL (varies by lot)
• Sequence Length: 189

• Applicable Applications for anti-DAND5 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:25-1:100; ELISA: 1:5000-1:10000
• Immunogen: Full length fusion protein
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using DAND5 Polyclonal Antibody at dilution of 1:25(×200))

Related Product Information for anti-DAND5 antibody

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry.

NCBI and Uniprot Product Information

• NCBI GI #: 22749329
• NCBI GeneID: 199699
• NCBI Accession #: NP_689867; BC113476
• NCBI GenBank Nucleotide #: NP_689867.1
• UniProt Accession #: Q8N907
• NCBI Official Full Name: DAN domain family member 5
• NCBI Official Synonym Full Names: DAN domain BMP antagonist family member 5
• NCBI Official Symbol: DAND5
• NCBI Official Synonym Symbols: SP1; CER2; COCO; CRL2; CERL2; DANTE; GREM3; CKTSF1B3
• NCBI Protein Information: DAN domain family member 5
• UniProt Protein Name: DAN domain family member 5
• Protein Family: DAN domain family
• UniProt Gene Name: DAND5
• UniProt Synonym Gene Names: CER2; CKTSF1B3; GREM3; SP1; Cerl-2
• UniProt Entry Name: DAND5_HUMAN

NCBI Description

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq, Jul 2008]

Uniprot Description

DAND5: Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation. Belongs to the DAN family.

Protein type: Secreted, signal peptide; Secreted; Cell development/differentiation

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: extracellular region

Molecular Function: morphogen activity

Biological Process: negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of BMP signaling pathway