Western Blot (WB)
(DACH1 Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the DACH1 antibody detected the DACH1 protein (arrow).)
Rabbit anti-Human, mouse DACH1 Polyclonal Antibody | anti-DACH1 antibody
DACH1 Antibody (Center)
Western Blot (WB)
(DACH1 Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the DACH1 antibody detected the DACH1 protein (arrow).)
Western Blot (WB)
(DACH1 Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the DACH1 antibody detected the DACH1 protein (arrow).)
associates with other DNA-binding transcription factors to regulate
gene expression and cell fate determination during development. The
protein contains a Ski domain that is highly conserved from
Drosophila to human. Expression of this gene is lost in some forms
of metastatic cancer, and is correlated with poor prognosis.
Multiple transcript variants encoding different isoforms have been
found for this gene.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)
Zhou, J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(15):6864-6869(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Uniprot Description
DACH1: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin- dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain. Belongs to the DACH/dachshund family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 13q22
Cellular Component: nucleoplasm; transcription factor complex; intracellular membrane-bound organelle; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; DNA binding
Biological Process: cell proliferation; development of primary female sexual characteristics; suckling behavior; negative regulation of fibroblast proliferation; respiratory gaseous exchange; negative regulation of transcription from RNA polymerase II promoter; transcriptional preinitiation complex assembly; negative regulation of cell migration
Research Articles on DACH1
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Product Notes
The DACH1 dach1 (Catalog #AAA9201067) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 270-297. The DACH1 Antibody (Center) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's DACH1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the DACH1 dach1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DACH1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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