Rabbit anti-Human, Mouse D52 / TPD52 Polyclonal Antibody | anti-D52 antibody

Rabbit Polyclonal (IgG) to Human D52 / TPD52

Cat. Num. AAA244635

• Gene Names: TPD52; D52; N8L; PC-1; PrLZ; hD52
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: D52 / TPD52; Polyclonal Antibody; Rabbit Polyclonal (IgG) to Human D52 / TPD52; Anti-D52 / TPD52 Antibody (aa41-90) IHC-plus; TPD52; D52; HD52; PrLZ; Prostate leucine zipper; Protein N8; Tumor protein D52; N8L; Pc-1; Human D52; anti-D52 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TPD52 Antibody detects endogenous levels of total TPD52 protein.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 184

• Applicable Applications for anti-D52 antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA (1:40000), IHC-P (5 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic peptide from human TPD52 (aa41-90).
• Immunogen: D52 / TPD52 antibody was raised against synthetic peptide from human TPD52 (aa41-90).
• Antigen Modification: aa41-90
• Preparation and Storage: Store at -20 degree C for up to one year.

Immunohistochemistry (IHC)

(Anti-PC-1 / TPD52 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 4827038
• NCBI GeneID: 7163
• NCBI Accession #: NP_005070.1
• NCBI GenBank Nucleotide #: NM_005079.3
• UniProt Accession #: P55327; Q13056; Q53EK8; Q6FGP3; B7Z414; C9J502; D0UFD1; D0UFD2; D0UFD3; D0UFD4; D0UFD5; E5RKB4
• Molecular Weight: 16,853 Da
• NCBI Official Full Name: tumor protein D52 isoform 3
• NCBI Official Synonym Full Names: tumor protein D52
• NCBI Official Symbol: TPD52
• NCBI Official Synonym Symbols: D52; N8L; PC-1; PrLZ; hD52
• NCBI Protein Information: tumor protein D52; protein N8; prostate leucine zipper; prostate and colon associated protein
• UniProt Protein Name: Tumor protein D52
• UniProt Gene Name: TPD52
• UniProt Entry Name: TPD52_HUMAN

Uniprot Description

TPD52: a coiled-coil motif bearing hydrophilic protein known to be overexpressed in many human solid tumors of diverse cellular origins. May be associated with B cell differentiation. Increased expression is associated with increased proliferation and invasive capacity in different cell types. May negatively regulate ATM protein levels. Isoform 2 is expressed in colon, breast, prostate, pancreas and kidney tumor cell lines. Isoform 2 is expressed at high levels in kidney, prostate, brain, small intestine and pancreas, at moderate levels in placenta and colon, at low levels in lung, liver and heart, and at very low levels in spleen, thymus, peripheral mononuclear blood cells, testis and ovary. Isoform 2 is expressed at lower levels in fetal brain and kidney than in adult brain and kidney. Eight isoforms of the human protein are produced by alternative splicing

Protein type: Endoplasmic reticulum; Calcium-binding

Chromosomal Location of Human Ortholog: 8q21.13

Cellular Component: perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm

Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; calcium ion binding

Biological Process: anatomical structure morphogenesis; secretion; B cell differentiation; positive regulation of cell proliferation