anti-Human Cytochrome P450 1B1 Polyclonal Antibody | anti-CYP1B1 antibody
Anti - Cytochrome P450 1B1 (CYP1B1)
Gene Names
CYP1B1; CP1B; GLC3A; P4501B1
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Serum
Synonyms
Cytochrome P450 1B1; Polyclonal Antibody; Anti - Cytochrome P450 1B1 (CYP1B1); Cytochrome P450 1B1 (CYP1B1); anti-CYP1B1 antibody
Host
Host: Rabbit
Source: Human
Source: Human
Reactivity
Human
Clonality
Polyclonal
Specificity
Recognizes human CYP1B1. Human CYP1B1 sequence is 92% conserved in chimp protein. It is only 35% conserved in mouse/rat Cyp1B1.
Purity/Purification
Serum
Form/Format
Serum
Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide, before the addition of glycerol to 40%.
Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide, before the addition of glycerol to 40%.
Sequence Length
543
Applicable Applications for anti-CYP1B1 antibody
ELISA, Western Blot
Application Notes
Western Blot (1:500-1:1000).
ELISA (1:100,000 using 50-100ng control peptide/well).
ELISA (1:100,000 using 50-100ng control peptide/well).
Immunogen
14aa peptide from C-terminus of human CYP1B1, conjugated to KLH.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-CYP1B1 antibody
Cytochrome P450 (P450 or CYP) enzymes, a superfamilyof b-type heme-containing proteins found in organisms from alldomains of life, are major catalysts in the oxidative transformationof a diversity of endogenous and exogenous compounds. CYP enzymes play an important role in the metabolic activation of environmentalprocarcinogens or chemical carcinogenesis, these enzymes are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.
Product Categories/Family for anti-CYP1B1 antibody
References
• Tsuchiya Y, 2004, Cancer Res.,64: 3119, IHCRagavan N, 2004, Cancer Lett 215, 69-78, IHCScallet AC, 2005, J. Chem. Neuroanatomy, 29, 71-80 WB, IHC
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
60,846 Da
NCBI Official Full Name
cytochrome P450 1B1
NCBI Official Synonym Full Names
cytochrome P450, family 1, subfamily B, polypeptide 1
NCBI Official Symbol
CYP1B1
NCBI Official Synonym Symbols
CP1B; GLC3A; P4501B1
NCBI Protein Information
cytochrome P450 1B1; CYPIB1; OTTHUMP00000126963; OTTHUMP00000201401; microsomal monooxygenase; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile)
UniProt Protein Name
Cytochrome P450 1B1
Protein Family
UniProt Gene Name
CYP1B1
UniProt Entry Name
CP1B1_HUMAN
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Product Notes
The CYP1B1 cyp1b1 (Catalog #AAA617235) is an Antibody produced from Host: Rabbit Source: Human and is intended for research purposes only. The product is available for immediate purchase. The Anti - Cytochrome P450 1B1 (CYP1B1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Cytochrome P450 1B1 can be used in a range of immunoassay formats including, but not limited to, ELISA, Western Blot. Western Blot (1:500-1:1000). ELISA (1:100,000 using 50-100ng control peptide/well). Researchers should empirically determine the suitability of the CYP1B1 cyp1b1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cytochrome P450 1B1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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