Rabbit anti-Human KLHDC8B Polyclonal Antibody | anti-KLHDC8B antibody

KLHDC8B, CT (KLHDC8B, Kelch domain-containing protein 8B) (AP)

Cat. Num. AAA6314095

• Gene Names: KLHDC8B; CHL
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KLHDC8B; Polyclonal Antibody; CT (KLHDC8B; Kelch domain-containing protein 8B) (AP); Kelch domain-containing protein 8B; anti-KLHDC8B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-KLHDC8B antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KLHDC8B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 244-273 amino acids from the C-terminal region of human KLHDC8B.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(KLHDC8B Antibody (C-term) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the KLHDC8B antibody detected the KLHDC8B protein (arrow).)

Related Product Information for anti-KLHDC8B antibody

This gene encodes a protein which forms a distinct beta-propeller protein structure of kelch domains allowing for protein-protein interactions. Mutations in this gene have been associated with Hodgkin lymphoma.

Product Categories/Family for anti-KLHDC8B antibody

Antibodies; Kelch Proteins

References

Krem, M.M., et al. Cell Cycle 9(4):670-675(2010). Salipante, S.J., et al. Proc. Natl. Acad. Sci. U.S.A. 106(35):14920-14925(2009). Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004). Adams, M.D., et al. Nat. Genet. 4(4):373-380(1993).

NCBI and Uniprot Product Information

• NCBI GI #: 27734909
• NCBI GeneID: 200942
• NCBI Accession #: NP_775817.1
• NCBI GenBank Nucleotide #: NM_173546.2
• UniProt Accession #: Q8IXV7
• Molecular Weight: 37,676 Da
• NCBI Official Full Name: kelch domain-containing protein 8B
• NCBI Official Synonym Full Names: kelch domain containing 8B
• NCBI Official Symbol: KLHDC8B
• NCBI Official Synonym Symbols: CHL
• NCBI Protein Information: kelch domain-containing protein 8B
• UniProt Protein Name: Kelch domain-containing protein 8B
• Protein Family: Kelch domain-containing protein
• UniProt Gene Name: KLHDC8B
• UniProt Entry Name: KLD8B_HUMAN

Uniprot Description

KLHDC8B: Defects in KLHDC8B are a cause of Hodgkin lymphoma (HL). A malignant disease characterized by progressive enlargement of the lymph nodes, spleen and general lymphoid tissue, and the presence of large, usually multinucleate, cells (Reed-Sternberg cells). Reed-Sternberg cells compose only 1-2% of the total tumor cell mass. The remainder is composed of a variety of reactive, mixed inflammatory cells consisting of lymphocytes, plasma cells, neutrophils, eosinophils and histiocytes. A chromosomal aberration disrupting KLHDC8B has been found in a family with the nodular sclerosis type of classic Hodgkin lymphoma. Translocation t(2,3)(q11.2;p21.31).

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: cytoplasm

Disease: Leg, Absence Deformity Of, With Congenital Cataract