Western Blot (WB)
(Western Blot analysis of CYP46A1 expression in transfected 293T cell line by CYP46A1 polyclonal antibody. Lane 1: CYP46A1 transfected lysate (56.8kD). Lane 2: Non-transfected lysate.)
Rabbit anti-Human CYP46A1 Polyclonal Antibody | anti-CYP46A1 antibody
CYP46A1 (Cytochrome P450 46A1, Cholesterol 24-hydroxylase, CH24H, CYP46) (AP)
Western Blot (WB)
(Western Blot analysis of CYP46A1 expression in transfected 293T cell line by CYP46A1 polyclonal antibody. Lane 1: CYP46A1 transfected lysate (56.8kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of CYP46A1 expression in transfected 293T cell line by CYP46A1 polyclonal antibody. Lane 1: CYP46A1 transfected lysate (56.8kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008]
Uniprot Description
CYP46A1: Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Belongs to the cytochrome P450 family.
Protein type: EC 1.14.13.98; Lipid Metabolism - primary bile acid biosynthesis; Membrane protein, integral; Oxidoreductase
Chromosomal Location of Human Ortholog: 14q32.1
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane
Molecular Function: iron ion binding; cholesterol 24-hydroxylase activity; heme binding; steroid hydroxylase activity
Biological Process: nervous system development; bile acid biosynthetic process; bile acid metabolic process; xenobiotic metabolic process; cholesterol catabolic process; sterol metabolic process
Research Articles on CYP46A1
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Product Notes
The CYP46A1 cyp46a1 (Catalog #AAA6375512) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CYP46A1 (Cytochrome P450 46A1, Cholesterol 24-hydroxylase, CH24H, CYP46) (AP) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CYP46A1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the CYP46A1 cyp46a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CYP46A1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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