Rabbit anti-Human Cyclin G1 Polyclonal Antibody | anti-CCNG1 antibody

Rabbit anti Cyclin G1 Polyclonal Antibody

Cat. Num. AAA460027

• Gene Names: CCNG1; CCNG
• Reactivity: Human
• Applications: ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry, Immunoprecipitation, Western Blot
• Purity: Purified by Epitope Affinity Purification
• Synonyms: Cyclin G1; Polyclonal Antibody; Rabbit anti Cyclin G1 Polyclonal Antibody; CCNG1; anti-CCNG1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: This antibody reacts with human. The other species are not tested.
• Purity/Purification: Purified by Epitope Affinity Purification
• Form/Format: Supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Sequence Length: 295

• Applicable Applications for anti-CCNG1 antibody: ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: ELISA: 0.01-0.1 ug/ml; Flow Cytometry: 5-10 ug/ml; Immunohistochemistry: 2-10 ug/ml; Immunoprecipitation: 2-5 ug/ml; Western Blot: 0.1-1 ug/ml
• Preparation: A synthetic peptide corresponding to C-terminal of human cyclin G1. This sequence is identical to human, mouse and rat.
• Preparation and Storage: The antibodies are stable for 12 months from date of receipt when stored at -20 degree C. The antibodies can be stored at 2 degree C - 8 degree C for one month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

Related Product Information for anti-CCNG1 antibody

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The Cyclin G contains a typical N terminal cyclin box and a carboxy terminal domain sequence homologous to the tyrosine phosphorylation site of the epidermal growth factor receptor. Cyclin G2 shares 53% amino acid sequence identity with cyclin G1. Peak expression of cyclin G2 is seen in late S phase, as opposed to cyclin G1 expression. It is p53-responsive gene that the transcriptional activation of Cyclin G1 can be induced by tumor protein p53.

References

Fornari F et al, MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells. Cancer Res. 69 (14):5761-7 (2009).

NCBI and Uniprot Product Information

• NCBI GI #: 1236233
• NCBI GeneID: 900
• Molecular Weight: 18,769 Da
• NCBI Official Full Name: cyclin G1
• NCBI Official Synonym Full Names: cyclin G1
• NCBI Official Symbol: CCNG1
• NCBI Official Synonym Symbols: CCNG
• NCBI Protein Information: cyclin-G1
• UniProt Protein Name: Cyclin-G1
• Protein Family: Cyclin
• UniProt Gene Name: CCNG1
• UniProt Synonym Gene Names: CCNG; CYCG1; Cyclin-G

NCBI Description

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

CCNG1: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation. Belongs to the cyclin family. Cyclin G subfamily.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: nucleoplasm

Molecular Function: protein binding

Biological Process: regulation of cyclin-dependent protein kinase activity