Western Blot (WB)
(Western Blot (WB) analysis of AR-beta3 (L291) polyclonal antibody at 1:500 dilutionLane1:MCF-7 cell lysateLane2:Mouse kidney tissue lysateLane3:Rat liver tissue lysate)
Rabbit AR-beta3 Polyclonal Antibody | anti-AR3 antibody
AR-beta3 (L291) Polyclonal Antibody
Gene Names
ADRB3; BETA3AR
Reactivity
Human, Mouse, Rat
Applications
Western Blot
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
AR-beta3; Polyclonal Antibody; AR-beta3 (L291) Polyclonal Antibody; Beta-3 adrenergic receptor; Beta-3 adrenoreceptor; Beta-3 adrenoceptor; ADRB3; ADRB3R; B3AR; AR beta3; ARbeta3; beta3-AR; beta3 AR; beta3AR; anti-AR3 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
AR-beta3 (L291) polyclonal antibody detects endogenous levels of AR-beta3 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
408
Applicable Applications for anti-AR3 antibody
Western Blot (WB)
Application Notes
WB: 1:500-1:1000
Immunogen
Synthetic peptide, corresponding to amino acids 250-300 of Human AR-beta3.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Western Blot (WB)
(Western Blot (WB) analysis of AR-beta3 (L291) polyclonal antibody at 1:500 dilutionLane1:MCF-7 cell lysateLane2:Mouse kidney tissue lysateLane3:Rat liver tissue lysate)
Western Blot (WB)
(Western Blot (WB) analysis of AR-beta3 (L291) polyclonal antibody at 1:500 dilutionLane1:MCF-7 cell lysateLane2:Mouse kidney tissue lysateLane3:Rat liver tissue lysate)
Related Product Information for anti-AR3 antibody
Beta 3-adrenergic receptors (b3-ARs) bind cathecholamines (epinephrine, norepinephrine), and primarily regulate lipolysis and thermogenesis in adipose. b3-ARs are present in adipose tissues, heart, and in smooth muscle of bladder, colon, small intestine, and stomach. The human corpus cavernosum exhibits basal b3-AR-mediated vasorelaxant tone and activity is linked to inhibition of the RhoA/Rho-kinase pathway. b3-AR interacts directly with the SH3 domain of Src through proline-rich motifs (PXXP) in the third intracellular loop and the carboxy-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~ 43, 68kDa
NCBI Official Full Name
beta-3 adrenergic receptor
NCBI Official Synonym Full Names
adrenoceptor beta 3
NCBI Official Symbol
ADRB3
NCBI Official Synonym Symbols
BETA3AR
NCBI Protein Information
beta-3 adrenergic receptor
UniProt Protein Name
Beta-3 adrenergic receptor
UniProt Gene Name
ADRB3
UniProt Synonym Gene Names
ADRB3R; B3AR; Beta-3 adrenoceptor
UniProt Entry Name
ADRB3_HUMAN
NCBI Description
The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Obesity and bodyweight-related disorders are correlated with certain polymorphisms in three subtypes of beta-adrenoceptor, among them, the ADRB3 gene.[provided by RefSeq, Oct 2019]
Research Articles on AR3
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Product Notes
The AR3 adrb3 (Catalog #AAA3003486) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The AR-beta3 (L291) Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's AR-beta3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:1000. Researchers should empirically determine the suitability of the AR3 adrb3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AR-beta3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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