Rabbit anti-Rat Cyclin Dependent Kinase Inhibitor 1A (CDKN1A) Polyclonal Antibody | anti-CDKN1A antibody
Biotin-Linked Polyclonal Antibody to Cyclin Dependent Kinase Inhibitor 1A (CDKN1A)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015]
Uniprot Description
p21Cip1: a cell-cycle regulatory protein that Interacts with cyclin-CDK2 and -CDK4, inhibiting cell cycle progression at G1. Its expression is tightly controlled by p53, through which this protein mediates the p53-dependent cell cycle arrest at G1 phase.
Protein type: Cell cycle regulation; Inhibitor
Chromosomal Location of Human Ortholog: 6p21.2
Cellular Component: cyclin-dependent protein kinase holoenzyme complex; cytosol; nuclear body; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein complex
Molecular Function: cyclin binding; cyclin-dependent protein kinase activating kinase activity; cyclin-dependent protein kinase activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; metal ion binding; protein binding; protein complex binding; protein kinase binding; protein kinase inhibitor activity; ubiquitin protein ligase binding
Biological Process: cell cycle arrest; cellular response to amino acid starvation; cellular response to DNA damage stimulus; cellular response to extracellular stimulus; cellular response to gamma radiation; cellular response to heat; cellular response to ionizing radiation; cellular response to UV-B; cellular senescence; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; mitotic cell cycle arrest; negative regulation of apoptosis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; negative regulation of phosphorylation; organ regeneration; positive regulation of B cell proliferation; positive regulation of cyclin-dependent protein kinase activity; positive regulation of fibroblast proliferation; positive regulation of programmed cell death; positive regulation of protein kinase activity; positive regulation of reactive oxygen species metabolic process; protein kinase B signaling; protein stabilization; Ras protein signal transduction; regulation of cyclin-dependent protein kinase activity; regulation of DNA biosynthetic process; regulation of protein import into nucleus, translocation; regulation of transcription from RNA polymerase II promoter; replicative senescence; response to arsenic; response to corticosterone stimulus; response to drug; response to hyperoxia; response to organonitrogen compound; response to toxin; response to X-ray; stress-induced premature senescence; transcription initiation from RNA polymerase II promoter
Research Articles on CDKN1A
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Product Notes
The CDKN1A cdkn1a (Catalog #AAA2095768) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Biotin-Linked Polyclonal Antibody to Cyclin Dependent Kinase Inhibitor 1A (CDKN1A) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Cyclin Dependent Kinase Inhibitor 1A (CDKN1A) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the CDKN1A cdkn1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cyclin Dependent Kinase Inhibitor 1A (CDKN1A), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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