Rabbit Cyclin D1 Polyclonal Antibody | anti-Ccnd1 antibody

Cyclin D1 Antibody FITC Conjugated

Cat. Num. AAA9459954

• Gene Names: Ccnd1; cD1; CycD1; Cyl-1; PRAD1; bcl-1; AI327039
• Reactivity: Human, Mouse, Rat, Goat
• Applications: Immunofluorescence, Flow Cytometry, Functional Assay
• Purity: Purified by Protein A
• Synonyms: Cyclin D1; Polyclonal Antibody; Cyclin D1 Antibody FITC Conjugated; cD1; CycD1; Cyl-1; PRAD1; bcl-1; AI32739; G1 S-specific cyclin-D1; Ccnd1; anti-Ccnd1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat, Goat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A
• Form/Format: 10mM Tris Buffered Saline containing 1% BSA, 50% glycerol and 0.09% sodium azide.
• Concentration: 1mgml (varies by lot)

• Applicable Applications for anti-Ccnd1 antibody: Immunofluorescence (IF), Flow Cytometry (FC/FACS)
• Application Notes: FC/FACS: 1:20-100; IF: 1:50-200
• Conjugation: FITC
• Excitation Emission: 494nm 518nm
• Immunogen: KLH conjugated synthetic peptide aa 70-120 295 derived from mouse Cyclin D1
• Preparation and Storage: Store at 4 degree C for 12 months.

Related Product Information for anti-Ccnd1 antibody

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G (1) S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G (1) phase. Hypophosphorylates RB1 in early G (1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1 CDK4 CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (By similarity).

Product Categories/Family for anti-Ccnd1 antibody

Conjugated Primary Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 116153
• NCBI GeneID: 12443
• UniProt Accession #: P25322
• Molecular Weight: 33,429 Da
• NCBI Official Full Name: G1/S-specific cyclin-D1
• NCBI Official Synonym Full Names: cyclin D1
• NCBI Official Symbol: Ccnd1
• NCBI Official Synonym Symbols: cD1; CycD1; Cyl-1; PRAD1; bcl-1; AI327039
• NCBI Protein Information: G1/S-specific cyclin-D1
• UniProt Protein Name: G1/S-specific cyclin-D1
• Protein Family: G1/S-specific cyclin
• UniProt Gene Name: Ccnd1
• UniProt Synonym Gene Names: Cyl-1
• UniProt Entry Name: CCND1_MOUSE

Uniprot Description

CCND1: a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb.

Protein type: Nuclear receptor co-regulator; Activator; Cell cycle regulation; Oncoprotein

Cellular Component: nucleoplasm; tight junction; membrane; transcriptional repressor complex; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; intracellular; nucleus

Molecular Function: protein binding; enzyme binding; histone deacetylase binding; protein complex binding; kinase activity; cyclin-dependent protein kinase regulator activity; transcription corepressor activity; transcription factor binding; protein kinase binding; protein kinase activity

Biological Process: lactation; fat cell differentiation; G1 DNA damage checkpoint; negative regulation of Wnt receptor signaling pathway; re-entry into mitotic cell cycle; positive regulation of cyclin-dependent protein kinase activity; regulation of cell cycle; positive regulation of mammary gland epithelial cell proliferation; negative regulation of epithelial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; protein amino acid phosphorylation; Leydig cell differentiation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; Wnt receptor signaling pathway; transcription, DNA-dependent; unfolded protein response; mammary gland epithelial cell proliferation; response to organic nitrogen; cell cycle; cell division; positive regulation of protein amino acid phosphorylation; regulation of cyclin-dependent protein kinase activity; regulation of protein kinase activity; response to DNA damage stimulus; G1/S transition of mitotic cell cycle