Rabbit anti-Human, Mouse CXCR7 Polyclonal Antibody | anti-CXCR7 antibody

CXCR7, CT (G-protein Coupled Receptor 159, Chemokine Orphan Receptor 1, G-protein Coupled Receptor RDC1 Homolog, RDC-1, C-X-C Chemokine Receptor Type 7, CXC-R7, CXCR-7, CMKOR1, GPR159, RDC1) (Biotin)

Cat. Num. AAA6471110

• Gene Names: CXCR7; RDC1; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159
• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: Purified by Immunoaffinity chromatography.
• Synonyms: CXCR7; Polyclonal Antibody; CT (G-protein Coupled Receptor 159; Chemokine Orphan Receptor 1; G-protein Coupled Receptor RDC1 Homolog; RDC-1; C-X-C Chemokine Receptor Type 7; CXC-R7; CXCR-7; CMKOR1; GPR159; RDC1) (Biotin); anti-CXCR7 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CXCR7. Species Crossreactivity: mouse.
• Purity/Purification: Purified by Immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-CXCR7 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-1:500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide selected from the C-term region of human CXCR7 (KLH).
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of CXCR7 Antibody (C-term) in mouse lung tissue and Ramos cell line lysates (35ug/lane). CXCR7 (arrow) was detected using the purified Pab.)

Immunohistochemistry (IHC)

(Formalin-fixed and paraffin-embedded human testis tissue reacted with CXCR7 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)

Product Categories/Family for anti-CXCR7 antibody

Antibodies; G Protein Receptors

References

1. Sreedharan, S.P., et.al., Proc. Natl. Acad. Sci. USA 88(11), 4986-4990 (1991).

NCBI and Uniprot Product Information

• NCBI GI #: 31083344
• NCBI GeneID: 57007
• NCBI Accession #: NP_064707.1
• NCBI GenBank Nucleotide #: NM_020311.2
• UniProt Accession #: P25106; Q53RV4; Q8NE10; Q92938; Q92986; A8K6J4
• Molecular Weight: 41,493 Da
• NCBI Official Full Name: C-X-C chemokine receptor type 7
• NCBI Official Synonym Full Names: chemokine (C-X-C motif) receptor 7
• NCBI Official Symbol: CXCR7
• NCBI Official Synonym Symbols: RDC1; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159
• NCBI Protein Information: C-X-C chemokine receptor type 7; G protein-coupled receptor; chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog
• UniProt Protein Name: C-X-C chemokine receptor type 7
• UniProt Gene Name: CXCR7
• UniProt Synonym Gene Names: CMKOR1; GPR159; RDC1; CXC-R7; CXCR-7; RDC-1
• UniProt Entry Name: CXCR7_HUMAN

NCBI Description

This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008]

Uniprot Description

CMKOR1: Receptor for chemokines CXCL12/SDF1 and CXCL11. Does not elicit classical chemokine receptor signaling; chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Acts as a scavenger for CXCL12/SDF1 and, to a lesser extent, for CXCL11. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: recycling endosome; cell surface; perinuclear region of cytoplasm; early endosome; plasma membrane; integral to membrane; coated pit; endosome

Molecular Function: C-X-C chemokine binding; protein binding; coreceptor activity; scavenger receptor activity; C-X-C chemokine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; viral reproduction; receptor internalization; angiogenesis; cell adhesion; vasculogenesis; chemotaxis