Rabbit CXCR1 Polyclonal Antibody | anti-CXCR1 antibody

Rabbit Polyclonal to Human CXCR1

Cat. Num. AAA243295

• Gene Names: CXCR1; C-C; CD128; CD181; CKR-1; IL8R1; IL8RA; CMKAR1; IL8RBA; CDw128a; C-C-CKR-1
• Reactivity: Human; Predicted Reactivity: Chimpanzee, Gorilla (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry, Immunocytochemistry
• Purity: Immunoaffinity Purified
• Synonyms: CXCR1; Polyclonal Antibody; Rabbit Polyclonal to Human CXCR1; Anti-CXCR1 Antibody (N-Terminus) IHC-plus; C-C; Chemokine c-x-c receptor 1; CKR-1; CMKAR1; CD128; CD181; CD181 antigen; CXCR-1; CXC-R1; IL-8R A; Il8 receptor a; Interleukin 8 receptor a; Interleukin 8 receptor alpha; Interleukin 8 receptor; alpha; Interleukin-8 receptor type A; IL8RBA; Human CXCR1; anti-CXCR1 antibody

• Host: Rabbit
• Reactivity: Human; Predicted Reactivity: Chimpanzee, Gorilla (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human CXCR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 350

• Applicable Applications for anti-CXCR1 antibody: Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC)
• Application Notes: ICC, IHC-P (7 - 11 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 20 amino acid peptide from N-terminal extracellular domain of human CXCR1. Percent identity with other species by BLAST analysis: Human (100%); Gorilla (95%); Chimpanzee (90%); Monkey (80%).
• Immunogen Type: Synthetic peptide
• Immunogen: CXCR1 antibody was raised against synthetic 20 amino acid peptide from N-terminal extracellular domain of human CXCR1. Percent identity with other species by BLAST analysis: Human (100%); Gorilla (95%); Chimpanzee (90%); Monkey (80%).
• Antigen Modification: N-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-CXCR1 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-CXCR1 antibody IHC of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Transfection

(Anti-CXCR1 antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with CXCR1.)

Transfection Control

(Anti-CXCR1 antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.)

Related Product Information for anti-CXCR1 antibody

CXCR1, also known as Interleukin 8 Receptor A (IL8RA), is a Chemokine Receptor also known as type 2 interleukin-8 receptor. There are three interleukin-8 receptors on chromosome 2: IL8RA, IL8RB (type 1), and a pseudogene. IL8RA is activated by interleukin-8, growth-regulated peptide (GRO), and neutrophil-activating peptide 2 (NAP-2). It is expressed in neutrophils and lymphocytes but not in eosinophils.

Product Categories/Family for anti-CXCR1 antibody

Family: GPCR; Subfamily: Chemokine

NCBI and Uniprot Product Information

• NCBI GI #: 4504681
• NCBI GeneID: 3577
• NCBI Accession #: NP_000625.1
• NCBI GenBank Nucleotide #: NM_000634.2
• UniProt Accession #: P25024; Q2YEF8; Q2YEG4; Q2YEG5; Q2YEG7; Q2YEG8; Q53R18; Q6IN95; Q8N6T6; Q9P2T8; Q9P2T9; B2R6Q3
• Molecular Weight: 39,791 Da
• NCBI Official Full Name: C-X-C chemokine receptor type 1
• NCBI Official Synonym Full Names: chemokine (C-X-C motif) receptor 1
• NCBI Official Symbol: CXCR1
• NCBI Official Synonym Symbols: C-C; CD128; CD181; CKR-1; IL8R1; IL8RA; CMKAR1; IL8RBA; CDw128a; C-C-CKR-1
• NCBI Protein Information: C-X-C chemokine receptor type 1; CXC-R1; CXCR-1; IL-8R A; IL-8 receptor type 1; interleukin 8 receptor, alpha; interleukin-8 receptor type 1; interleukin-8 receptor type A; high affinity interleukin-8 receptor A
• UniProt Protein Name: C-X-C chemokine receptor type 1
• Protein Family: C-X-C chemokine receptor
• UniProt Gene Name: CXCR1
• UniProt Synonym Gene Names: CMKAR1; IL8RA; CXC-R1; CXCR-1; IL-8R A
• UniProt Entry Name: CXCR1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]

Uniprot Description

IL8RA: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, cytokine; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: membrane; plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity; interleukin-8 receptor activity; chemokine receptor activity; interleukin-8 binding

Biological Process: G-protein coupled receptor protein signaling pathway; cell surface receptor linked signal transduction; receptor internalization; dendritic cell chemotaxis; inflammatory response; chemotaxis

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To