Rabbit anti-Human, Mouse CUL9 Polyclonal Antibody | anti-CUL9 antibody
CUL9 Antibody
Gene Names
CUL9; PARC; H7AP1
Reactivity
Human, Mouse
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
CUL9; Polyclonal Antibody; CUL9 Antibody; CUL-9; Cul9; CUL9_HUMAN; Cullin-9; DKFZp686G1042; DKFZp686P2024; H7AP1; KIAA0708; OTTHUMP00000039816; p53 associated parkin like cytoplasmic protein; p53-associated parkin-like cytoplasmic protein; PARC; parkin-like cytoplasmic p53 binding protein; RP3 330M21.2; UbcH 7 associated protein 1; UbcH7 associated protein 1; UbcH7-associated protein 1; anti-CUL9 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
CUL9 Antibody detects endogenous levels of CUL9.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-CUL9 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human CUL9.
Conjugation
Unconjugated
Similarity
The IBR domain is required for interaction with UBCH7 and UBCH8. Belongs to the cullin family.
Post Translational Modifications
In vitro, self-ubiquitination in the presence of E1, E2 and ubiquitin.Neddylated.
Subunit Structure
Part of a Cul9-RING complex at least composed of CUL9 and RBX1. Interacts with CUL7: interaction with CUL7 component of the 3M complex leads to inhibition of CUL9 activity. The CUL7-CUL9 heterodimer seems to interact specifically with TP53. Forms a complex with p53/TP53 in the cytoplasm of unstressed cells. Interacts with UBCH7 and UBCH8.
Tissue Specificity
Ubiquitously expressed in all tissues with highest expression in testis brain and kidney.
Function
Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5. Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
268,362 Da
NCBI Official Full Name
cullin-9
NCBI Official Synonym Full Names
cullin 9
NCBI Official Symbol
CUL9
NCBI Official Synonym Symbols
PARC; H7AP1
NCBI Protein Information
cullin-9; CUL-9; UbcH7-associated protein 1; parkin-like cytoplasmic p53 binding protein; p53-associated parkin-like cytoplasmic protein
UniProt Protein Name
Cullin-9
Protein Family
UniProt Gene Name
CUL9
UniProt Synonym Gene Names
H7AP1; KIAA0708; PARC; CUL-9
UniProt Entry Name
CUL9_HUMAN
Uniprot Description
PARC: Cytoplasmic anchor protein in p53-associated protein complex. Regulates the subcellular localization of p53 and subsequent function. Seems to be part of an atypical cullin-RING- based E3 ubiquitin-protein ligase complex. In vitro, complexes of CUL9/PARC with either CUL7 or TP53 contain E3 ubiquitin-protein ligase activity. Belongs to the cullin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ligase; Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component: cullin-RING ubiquitin ligase complex; cytoplasm
Molecular Function: protein binding; zinc ion binding; ubiquitin protein ligase binding; ATP binding
Biological Process: ubiquitin-dependent protein catabolic process; regulation of mitosis; protein ubiquitination; microtubule cytoskeleton organization and biogenesis
Research Articles on CUL9
Similar Products
Product Notes
The CUL9 cul9 (Catalog #AAA9630945) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CUL9 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CUL9 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the CUL9 cul9 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CUL9, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
