Western Blot (WB)
(Western blot analysis of anti-CUL5 Antibody (C-term) in Hela cell line lysates (35ug/lane). CUL5 (arrow) was detected using the purified Pab.)
Rabbit CUL5 Polyclonal Antibody | anti-CUL5 antibody
CUL5 Antibody (C-term)
Western Blot (WB)
(Western blot analysis of anti-CUL5 Antibody (C-term) in Hela cell line lysates (35ug/lane). CUL5 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of anti-CUL5 Antibody (C-term) in Hela cell line lysates (35ug/lane). CUL5 (arrow) was detected using the purified Pab.)
Flow Cytometry (FC/FACS)
(Flow cytometric analysis of NCI-H292 cells using CUL5 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(Flow cytometric analysis of NCI-H292 cells using CUL5 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Immunohistochemistry (IHC)
(CUL5 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CUL5 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(CUL5 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CUL5 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Mehle A., Goncalves J., Santa-Marta M.Genes Dev. 18:2861-2866(2004)
Kamura T., Maenaka K., Kotoshiba S.Genes Dev. 18:3055-3065(2004)
NCBI and Uniprot Product Information
Uniprot Description
CUL5: a component of E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to be involved proteasomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. Member of the cullin family.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 11q22.3
Cellular Component: Cul5-RING ubiquitin ligase complex; plasma membrane; cytosol; nucleus
Molecular Function: protein binding; protein heterodimerization activity; calcium channel activity; ubiquitin protein ligase binding; receptor activity
Biological Process: ubiquitin-dependent protein catabolic process; negative regulation of cell proliferation; cell proliferation; cytosolic calcium ion homeostasis; viral reproduction; protein ubiquitination; cell cycle arrest; response to osmotic stress; G1/S transition of mitotic cell cycle
Research Articles on CUL5
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Product Notes
The CUL5 cul5 (Catalog #AAA9212647) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 747-774. The CUL5 Antibody (C-term) reacts with Human (Predicted Reactivity: Rabbit) and may cross-react with other species as described in the data sheet. AAA Biotech's CUL5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the CUL5 cul5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CUL5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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