Guinea pig CTRP1 Polyclonal Antibody | anti-C1QTNF1 antibody

CTRP1 (Complement C1q Tumor Necrosis Factor-related Protein 1, C1QTNF1, G Protein-coupled Receptor-interacting Protein, GIP)

Cat. Num. AAA641265

• Gene Names: C1QTNF1; GIP; CTRP1; ZSIG37
• Applications: ELISA, Western Blot, Immunoprecipitation
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: CTRP1; Polyclonal Antibody; CTRP1 (Complement C1q Tumor Necrosis Factor-related Protein 1; C1QTNF1; G Protein-coupled Receptor-interacting Protein; GIP); Anti -CTRP1 (Complement C1q Tumor Necrosis Factor-related Protein 1; anti-C1QTNF1 antibody

• Host: Guinea pig
• Clonality: Polyclonal
• Specificity: Recognizes a N-terminal region of CTRP1 full-length protein. Detects bands of ~17kD and ~36kD by Western blot. This antibody is CTRP1-specific.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in 0.2um-filtered PBS, pH 7.4. No preservative added.

• Applicable Applications for anti-C1QTNF1 antibody: ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: Suitable for use in ELISA, Immunoprecipitation, Western Blot
• Immunogen: Recombinant human CTRP1.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of recombinant human CTRPs using anti-CTRP1 (human), pAb at 1:4,000 dilution. 1: Recombinant human CTRP1 protein (His-tagged). 2: Unrelated recombinant protein (His-tagged).)

Immunoprecipitation (IP)

(Immunoprecipitation (IP) analysis of the cell lysates from HEK293 cells transfected with empty vector or a panel of the DYKDDDDK-tagged CTRP family (full-length) followed by immunoblot analysis using anti-CTRP1 (human), pAb at 1:4,000 dilution. The immunoblot (IB) analysis demonstrates the specificity of the anti-CTRP1 (human), pAb (Prod. No. AG-25A-0114) antibody. 3: hCTRP1-DYKDDDDK (full-length) transfected HEK293 cell lysates. 4: hCTRP2-DYKDDDDK (full-length) transfected HEK293 cell lysates. 5: hCTRP3-DYKDDDDK (full-length) transfected HEK293 cell lysates. 6: hCTRP5-DYKDDDDK (full-length) transfected HEK293 cell lysates. 7: hCTRP6-DYKDDDDK (full-length) transfected HEK293 cell lysates. 8: hCTRP7-DYKDDDDK (full-length) transfected HEK293 cell lysates. 9: hCTRP9-DYKDDDDK (full-length) transfected HEK293 cell lysates. 10: hCTRP10-DYKDDDDK (full-length) transfected HEK293 cell lysates. 11: hCTRP11-DYKDDDDK (full-length) transfected HEK293 cell lysates. 12: hCTRP13-DYKDDDDK (full-length) transfected HEK293 cell lysates. 13: Empty vector transfected HEK293 cell lysates.)

Related Product Information for anti-C1QTNF1 antibody

CTRP1 (Complement C1q tumor necrosis factor-related protein 1; C1QTNF1) belongs to a highly conserved family of adiponectin paralogs. Serum levels of CTRP1 are significantly higher in obese/diabetic animal models and in hypertensive patients compared to normal controls. CTRP1 may be a new molecular link between obesity and hypertension.

Product Categories/Family for anti-C1QTNF1 antibody

Antibodies; Abs to Growth Factors; Cytokines

NCBI and Uniprot Product Information

• NCBI GI #: 388453007
• NCBI GeneID: 114897
• NCBI Accession #: NP_699203.1
• NCBI GenBank Nucleotide #: NM_153372.1
• UniProt Accession #: Q9BXJ1; Q96NF2; Q9GZR4
• Molecular Weight: 31,743 Da
• NCBI Official Full Name: complement C1q tumor necrosis factor-related protein 1 isoform 1
• NCBI Official Synonym Full Names: C1q and tumor necrosis factor related protein 1
• NCBI Official Symbol: C1QTNF1
• NCBI Official Synonym Symbols: GIP; CTRP1; ZSIG37
• NCBI Protein Information: complement C1q tumor necrosis factor-related protein 1; G protein coupled receptor interacting protein; g protein-coupled receptor-interacting protein
• UniProt Protein Name: Complement C1q tumor necrosis factor-related protein 1
• Protein Family: Complement C1q tumor necrosis factor-related protein
• UniProt Gene Name: C1QTNF1
• UniProt Synonym Gene Names: CTRP1; GIP
• UniProt Entry Name: C1QT1_HUMAN

Uniprot Description

C1QTNF1: 2 isoforms of the human protein are produced by alternative splicing

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: extracellular space; collagen; integral to plasma membrane

Molecular Function: collagen binding; protein binding

Biological Process: positive regulation of protein kinase B signaling cascade; elevation of cytosolic calcium ion concentration; positive regulation of MAPKKK cascade; protein homooligomerization