Rabbit CTRP1 Polyclonal Antibody | anti-CTRP1 antibody

CTRP1 Antibody

Cat. Num. AAA9409210

• Gene Names: C1QTNF1; GIP; CTRP1; ZSIG37
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: CTRP1; Polyclonal Antibody; CTRP1 Antibody; G protein coupled receptor interacting protein 1; GIP; anti-CTRP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: These proteins are often highly modified post-translationally and migrate in SDS-PAGE at positions other than their predicted size.
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 281

• Applicable Applications for anti-CTRP1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 15 amino acid peptide from near the amino-terminus of human CTRP1.
• Target Name: CTRP1
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of CTRP1 in human kidney cell lysate with CTRP1 antibody at (A) 1 and (B) 2 ug/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of CTRP1 in human kidney tissue with CTRP1 antibody at 10 ug/mL.)

Related Product Information for anti-CTRP1 antibody

Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. In obese (ob/ob) mice, RT-PCR analysis showed that mCTRP1 transcripts are seen at substantially higher levels in adipose tissues compared to those of normal mice.

Product Categories/Family for anti-CTRP1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 38372917
• NCBI GeneID: 114897
• NCBI Accession #: NP_940995
• NCBI GenBank Nucleotide #: NM_198593.3
• Molecular Weight: 32,760 Da
• NCBI Official Full Name: complement C1q tumor necrosis factor-related protein 1 isoform 1
• NCBI Official Synonym Full Names: C1q and tumor necrosis factor related protein 1
• NCBI Official Symbol: C1QTNF1
• NCBI Official Synonym Symbols: GIP; CTRP1; ZSIG37
• NCBI Protein Information: complement C1q tumor necrosis factor-related protein 1
• UniProt Protein Name: Complement C1q tumor necrosis factor-related protein 1
• UniProt Gene Name: C1QTNF1
• UniProt Synonym Gene Names: CTRP1; GIP
• UniProt Entry Name: C1QT1_HUMAN

Uniprot Description

C1QTNF1: 2 isoforms of the human protein are produced by alternative splicing

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: extracellular space; collagen; integral to plasma membrane

Molecular Function: collagen binding; protein binding

Biological Process: positive regulation of protein kinase B signaling cascade; elevation of cytosolic calcium ion concentration; positive regulation of MAPKKK cascade; protein homooligomerization