Guinea pig CTRP5 Polyclonal Antibody | anti-C1QTNF5 antibody

CTRP5 (Complement C1q Tumor Necrosis Factor-related Protein 5, C1QTNF5)

Cat. Num. AAA6001222

• Gene Names: C1QTNF5; CTRP5
• Applications: ELISA, Western Blot, Immunoprecipitation
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: CTRP5; Polyclonal Antibody; CTRP5 (Complement C1q Tumor Necrosis Factor-related Protein 5; C1QTNF5); Anti -CTRP5 (Complement C1q Tumor Necrosis Factor-related Protein 5; anti-C1QTNF5 antibody

• Host: Guinea pig
• Clonality: Polyclonal
• Specificity: Recognizes a N-terminal region of CTRP5 full-length protein. Detects bands of ~15kD and ~26kD by Western blot. This antibody is CTRP5-specific.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in 0.2um-filtered PBS, pH 7.4. No preservative added.

• Applicable Applications for anti-C1QTNF5 antibody: ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: Suitable for use in ELISA, Immunoprecipitation, Western Blot
• Immunogen: Recombinant human CTRP5.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of recombinant human CTRPs using MBS6001222 at 1:4,000 dilution. 1: Recombinant human CTRP5 protein (His-tagged). 2: Unrelated recombinant protein (His-tagged).)

Immunoprecipitation (IP)

(Immunoprecipitation (IP) analysis of the cell lysates from HEK293 cells transfected with empty vector or a panel of the DYKDDDDK-tagged CTRP family (full-length) followed by immunoblot analysis using MBS6001222 at 1:4000 dilution. The immunoblot (IB) analysis demonstrates the specificity of the MBS6001222 antibody. 3: hCTRP1-DYKDDDDK (full-length) transfected HEK293 cell lysates. 4: hCTRP2-DYKDDDDK (full-length) transfected HEK293 cell lysates. 5: hCTRP3-DYKDDDDK (full-length) transfected HEK293 cell lysates. 6: hCTRP5-DYKDDDDK (full-length) transfected HEK293 cell lysates. 7: hCTRP6-DYKDDDDK (full-length) transfected HEK293 cell lysates. 8: hCTRP7-DYKDDDDK (full-length) transfected HEK293 cell lysates. 9: hCTRP9-DYKDDDDK (full-length) transfected HEK293 cell lysates. 10: hCTRP10-DYKDDDDK (full-length) transfected HEK293 cell lysates. 11: hCTRP11-DYKDDDDK (full-length) transfected HEK293 cell lysates. 12: hCTRP13-DYKDDDDK (full-length) transfected HEK293 cell lysates. 13: Empty vector transfected HEK293 cell lysates.)

Related Product Information for anti-C1QTNF5 antibody

CTRP5 (C1qTNF-related protein 5; C1QTNF5) belongs to a highly conserved family of adiponectin paralogs. CTRP5 mediates activation of AMP-activated protein kinase (AMPK) in muscle and liver cells, thereby regulating glucose and lipid metabolism. Serum levels of CTRP5 are significantly higher in obese/diabetic animal models compared to normal controls. Furthermore, CTRP5 may be a putative biomarker for mitochondrial dysfunction. Defects in C1QTNF5 are a cause of late-onset retinal degeneration (LORD).

Product Categories/Family for anti-C1QTNF5 antibody

Antibodies; Abs to Growth Factors; Cytokines

NCBI and Uniprot Product Information

• NCBI GI #: 510025462
• NCBI GeneID: 114902
• NCBI Accession #: NP_001265360.1
• NCBI GenBank Nucleotide #: NM_001278431.1
• UniProt Accession #: Q9BXJ0; Q335M2; Q8N6P2; Q9UFX4; A6NDD3; B0YJ35
• Molecular Weight: 25,298 Da
• NCBI Official Full Name: complement C1q tumor necrosis factor-related protein 5
• NCBI Official Synonym Full Names: C1q and tumor necrosis factor related protein 5
• NCBI Official Symbol: C1QTNF5
• NCBI Official Synonym Symbols: CTRP5
• NCBI Protein Information: complement C1q tumor necrosis factor-related protein 5; myonectin; C1q TNF-alpha-related protein 5
• UniProt Protein Name: Complement C1q tumor necrosis factor-related protein 5
• Protein Family: Complement C1q tumor necrosis factor-related protein
• UniProt Gene Name: C1QTNF5
• UniProt Synonym Gene Names: CTRP5
• UniProt Entry Name: C1QT5_HUMAN

NCBI Description

This gene encodes a member of a family of proteins that function as components of basement membranes and may play a role in cell adhesion. Mutations in this gene have been associated with late-onset retinal degeneration. The protein may be encoded by either a bicistronic transcript including sequence from the upstream membrane frizzled-related protein gene (MFRP), or by a monocistronic transcript expressed from an internal promoter. [provided by RefSeq, Jun 2013]

Uniprot Description

C1QTNF5: Defects in C1QTNF5 are a cause of late-onset retinal degeneration (LORD). LORD is an autosomal dominant disorder characterized by onset in the fifth to sixth decade with night blindness and punctate yellow-white deposits in the retinal fundus, progressing to severe central and peripheral degeneration, with choroidal neovascularization and chorioretinal atrophy.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: collagen

Disease: Late-onset Retinal Degeneration