Rabbit anti-Mouse Ctgf Polyclonal Antibody | anti-Ctgf antibody
Ctgf Antibody, Biotin conjugated
NCBI and Uniprot Product Information
Uniprot Description
CTGF: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Belongs to the CCN family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 10 A4|10 11.84 cM
Cellular Component: cell cortex; cis-Golgi network; cytosol; extracellular region; extracellular space; Golgi apparatus; intracellular membrane-bound organelle; perinuclear region of cytoplasm; proteinaceous extracellular matrix
Molecular Function: fibronectin binding; growth factor activity; heparin binding; integrin binding; protein C-terminus binding
Biological Process: angiogenesis; cartilage condensation; cell differentiation; cell migration; cell-cell signaling; cell-matrix adhesion; fibroblast growth factor receptor signaling pathway; integrin-mediated signaling pathway; lung development; ossification; positive regulation of caspase activity; positive regulation of cell activation; positive regulation of cell differentiation; positive regulation of cell proliferation; positive regulation of collagen biosynthetic process; positive regulation of JNK cascade; positive regulation of protein amino acid phosphorylation; positive regulation of stress fiber formation; regulation of chondrocyte differentiation; tissue homeostasis