Immunohistochemistry (IHC)
(Anti-CSTF1 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)
Rabbit CSTF1 Polyclonal Antibody | anti-CSTF1 antibody
Rabbit Polyclonal (IgG) to Human CSTF1
Immunohistochemistry (IHC)
(Anti-CSTF1 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)
Immunohistochemistry (IHC)
(Anti-CSTF1 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)
Western Blot (WB)
(Western blot of extracts from HUVEC/293 cells, using CSTF1 Antibody. The lane on the right is treated with the synthesized peptide.)
Western Blot (WB)
(Western blot of extracts from HUVEC/293 cells, using CSTF1 Antibody. The lane on the right is treated with the synthesized peptide.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
CSTF1: one of three subunits of cleavage stimulation factor (CSTF), a polyadenylation factor that cleaves the 3a??a??end of pre-mRNAs. Binds to the C-terminal ankyrin and tandem BRCT repeat domains of BARD1 (BRCA1-associated RING domain protein), modulating mRNA processing and RNAP II stability in response to DNA damage. The BARD1-CstF-50 interaction inhibits polyadenylation in vitro. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. WD domains are responsible for interaction with CSTF3. The sixth WD40 domain is required for interaction with BARD1.
Protein type: RNA-binding; RNA splicing
Chromosomal Location of Human Ortholog: 20q13.2
Cellular Component: nucleoplasm; intracellular membrane-bound organelle; cytoplasm; nucleus
Molecular Function: protein binding; RNA binding
Biological Process: nuclear mRNA splicing, via spliceosome; RNA processing; transcription from RNA polymerase II promoter; RNA splicing; gene expression; mRNA polyadenylation; mRNA 3'-end processing; termination of RNA polymerase II transcription; mRNA cleavage
Research Articles on CSTF1
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Product Notes
The CSTF1 cstf1 (Catalog #AAA248214) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal (IgG) to Human CSTF1 reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CSTF1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA). ELISA (1:20000), IHC-P (10 ug/ml), WB (1:500 - 1:1000). Researchers should empirically determine the suitability of the CSTF1 cstf1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CSTF1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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