Western Blot (WB)
(Mouse Cst3 Antibody (Center) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the Cst3 antibody detected the Cst3 protein (arrow).)
Rabbit Cst3 Polyclonal Antibody | anti-Cst3 antibody
Mouse Cst3 Antibody (Center)
Western Blot (WB)
(Mouse Cst3 Antibody (Center) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the Cst3 antibody detected the Cst3 protein (arrow).)
Western Blot (WB)
(Mouse Cst3 Antibody (Center) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the Cst3 antibody detected the Cst3 protein (arrow).)
Baston-Buest, D.M., et al. Reproduction 139(4):741-748(2010)
Frendeus, K.H., et al. Int. J. Biochem. Cell Biol. 41(11):2262-2269(2009)
Trimarchi, J.M., et al. Dev. Dyn. 238(9):2327-2329(2009)
Sun, B., et al. Neuron 60(2):247-257(2008)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a cysteine protease inhibitor involved in neurodegenerative and cardiovascular processes. The encoded protein inhibits aggregation of beta-amyloid protein, a hallmark of Alzheimer's disease, so it may be useful as a therapeutic. This protein also may be a biomarker for atherosclerosis. [provided by RefSeq, Aug 2015]
Uniprot Description
CST3: As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. Defects in CST3 are the cause of amyloidosis type 6 (AMYL6); also known as hereditary cerebral hemorrhage with amyloidosis (HCHWA), cerebral amyloid angiopathy (CAA) or cerebroarterial amyloidosis Icelandic type. AMYL6 is a hereditary generalized amyloidosis due to cystatin C amyloid deposition. Cystatin C amyloid accumulates in the walls of arteries, arterioles, and sometimes capillaries and veins of the brain, and in various organs including lymphoid tissue, spleen, salivary glands, and seminal vesicles. Amyloid deposition in the cerebral vessels results in cerebral amyloid angiopathy, cerebral hemorrhage and premature stroke. Cystatin C levels in the cerebrospinal fluid are abnormally low. Genetic variations in CST3 are associated with age- related macular degeneration type 11 (ARMD11). ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Belongs to the cystatin family.
Protein type: Secreted; Inhibitor; Secreted, signal peptide
Cellular Component: extracellular space; nuclear membrane; contractile fiber; endoplasmic reticulum; lysosome; extracellular region; multivesicular body; cell projection; cell soma; axon; perinuclear region of cytoplasm; cytoplasm; basement membrane; vesicle
Molecular Function: protease binding; protease inhibitor activity; beta-amyloid binding; endopeptidase inhibitor activity; cysteine protease inhibitor activity
Biological Process: negative regulation of proteolysis; positive regulation of cell proliferation; fibril organization and biogenesis; negative regulation of peptidase activity; defense response; response to oxidative stress; regulation of programmed cell death; positive regulation of DNA replication
Research Articles on Cst3
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Product Notes
The Cst3 cst3 (Catalog #AAA9209065) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 39-65. The Mouse Cst3 Antibody (Center) reacts with Mouse (Predicted Reactivity: Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's Cst3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the Cst3 cst3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cst3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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