Rabbit anti-Human CSRP3 Polyclonal Antibody | anti-CSRP3 antibody

CSRP3 Antibody (Center)

Cat. Num. AAA9210866

• Gene Names: CSRP3; CLP; MLP; CRP3; LMO4; CMD1M; CMH12
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: CSRP3; Polyclonal Antibody; CSRP3 Antibody (Center); Cysteine and glycine-rich protein 3; Cardiac LIM protein; Cysteine-rich protein 3; CRP3; LIM domain protein; cardiac; Muscle LIM protein; CLP; MLP; anti-CSRP3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This CSRP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-119 amino acids from the Central region of human CSRP3.
• Purity/Purification: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: Vial Concentration: 0.5 (varies by lot)
• Sequence Positions: 91-119
• Sequence Length: 194

• Applicable Applications for anti-CSRP3 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB~~1:1000
• Antigen Type: Synthetic Peptide
• Antigen Source: HUMAN
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(CSRP3 Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the CSRP3 antibody detected the CSRP3 protein (arrow).)

Related Product Information for anti-CSRP3 antibody

This gene encodes a member of the CSRP family of LIM
domain proteins, which may be involved in regulatory processes
important for development and cellular differentiation. The
LIM/double zinc-finger motif found in this protein is found in a
group of proteins with critical functions in gene regulation, cell
growth, and somatic differentiation. Mutations in this gene are
thought to cause heritable forms of hypertrophic cardiomyopathy
(HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively
spliced transcript variants with different 5' UTR, but encoding the
same protein, have been found for this gene.

Product Categories/Family for anti-CSRP3 antibody

Cardiovascular

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010)
Rampersaud, E., et al. Ann. Hum. Genet. 74(2):110-116(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Moller, D.V., et al. Eur. J. Heart Fail. 11(11):1031-1035(2009)

NCBI and Uniprot Product Information

• NCBI GI #: 4502893
• NCBI GeneID: 8048
• NCBI Accession #: NP_003467.1
• NCBI GenBank Nucleotide #: NM_003476.4
• UniProt Accession #: P50461; Q9P131
• Molecular Weight: 20969
• NCBI Official Full Name: cysteine and glycine-rich protein 3
• NCBI Official Synonym Full Names: cysteine and glycine-rich protein 3 (cardiac LIM protein)
• NCBI Official Symbol: CSRP3
• NCBI Official Synonym Symbols: CLP; MLP; CRP3; LMO4; CMD1M; CMH12
• NCBI Protein Information: cysteine and glycine-rich protein 3
• UniProt Protein Name: Cysteine and glycine-rich protein 3
• Protein Family: Cysteine and glycine-rich protein
• UniProt Gene Name: CSRP3
• UniProt Synonym Gene Names: CLP; MLP; CRP3
• UniProt Entry Name: CSRP3_HUMAN

NCBI Description

This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

CSRP3: Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation. Defects in CSRP3 are the cause of cardiomyopathy dilated type 1M (CMD1M). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in CSRP3 are the cause of familial hypertrophic cardiomyopathy type 12 (CMH12). Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.

Protein type: Transcription regulation

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: cytoskeleton; nucleus; Z disc

Molecular Function: actinin binding; protein binding; telethonin binding; zinc ion binding; structural constituent of muscle

Biological Process: cellular calcium ion homeostasis; cardiac muscle development; skeletal muscle development; protein localization in organelle; positive regulation of transcription from RNA polymerase II promoter; cardiac myofibril assembly; regulation of the force of heart contraction; cardiac muscle contraction

Disease: Cardiomyopathy, Familial Hypertrophic, 12; Cardiomyopathy, Dilated, 1m