Rabbit anti-Human CSRP3 Polyclonal Antibody | anti-CSRP3 antibody

CSRP3 Polyclonal Antibody

Cat. Num. AAA9133415

• Gene Names: CSRP3; CLP; MLP; CRP3; LMO4; CMD1M; CMH12
• Reactivity: Human
• Applications: Immunofluorescence
• Purity: Affinity Purification
• Synonyms: CSRP3; Polyclonal Antibody; CSRP3 Polyclonal Antibody; CLP; CMD1M; CMH12; CRP3; LMO4; MLP; anti-CSRP3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Sequence: MPNWGGGAKCGACEKTVYHAEEIQCNGRSFHKTCFHCMACRKALDSTTVAAHESEIYCKVCYGRRYGPKGIGYGQGAGCLSTDTGEHLGLQFQQSPKPARSVTTSNPSKFTAKFGESEKCPRCGKSVYAAEKVMGGGKPWHKTCFRCAICGKSLESTNVTDKDGELYCKVCYAKNFGPTGIGFGGLTQQVEKKE
• Sequence Length: 194

• Applicable Applications for anti-CSRP3 antibody: Immunofluorescence (IF)
• Application Notes: IF: 1:50 - 1:200
• Immunogen: Recombinant protein of human CSRP3
• Immunogen Species: Human
• Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Cellular Location: Cytoplasm, Nucleus, Z line, cytoskeleton, myofibril, sarcomere
• Preparation and Storage: Store at -20 degree C. Avoid freeze / thaw cycles.

Immunofluorescence (IF)

(Immunofluorescence analysis of HeLa cells using CSRP3 antibody. Blue: DAPI for nuclear staining.)

Related Product Information for anti-CSRP3 antibody

This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene.

Product Categories/Family for anti-CSRP3 antibody

Polyclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 4502893
• NCBI GeneID: 8048
• NCBI Accession #: NP_003467.1
• NCBI GenBank Nucleotide #: NM_003476.4
• UniProt Accession #: P50461; Q9P131; S4S7M7
• Molecular Weight: 6kDa/20kDa
• NCBI Official Full Name: cysteine and glycine-rich protein 3
• NCBI Official Synonym Full Names: cysteine and glycine rich protein 3
• NCBI Official Symbol: CSRP3
• NCBI Official Synonym Symbols: CLP; MLP; CRP3; LMO4; CMD1M; CMH12
• NCBI Protein Information: cysteine and glycine-rich protein 3
• UniProt Protein Name: Cysteine and glycine-rich protein 3
• Protein Family: Cysteine and glycine-rich protein
• UniProt Gene Name: CSRP3
• UniProt Synonym Gene Names: CLP; MLP; CRP3

NCBI Description

This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Positive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (). The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly: Shown to enhance CFL2-mediated F-actin depolymerization dependent on the CSRP3:CFL2 molecular ratio, and also shown to reduce the ability of CLF1 and CFL2 to enhance actin depolymerization (PubMed:19752190, PubMed:24934443). Proposed to contribute to the maintenance of muscle cell integerity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association (PubMed:24934443). In vitro can inhibit PKC/PRKCA activity (PubMed:27353086). Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling ().