Rabbit CSRP2 Polyclonal Antibody | anti-CSRP2 antibody

CSRP2 Antibody

Cat. Num. AAA9611672

• Gene Names: CSRP2; CRP2; LMO5; SmLIM
• Reactivity: Human, Mouse, Rat; Predicted: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
• Applications: Western Blot
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: CSRP2; Polyclonal Antibody; CSRP2 Antibody; anti-CSRP2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat; Predicted: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: CSRP2 Antibody detects endogenous levels of CSRP2.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 193

• Applicable Applications for anti-CSRP2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: A synthesized peptide derived from human CSRP2.
• Tissue Specificity: Highly expressed in the aorta, but not in heart and skeletal muscle.
• Fragment: Fab Fragment
• Conjugate: Unconjugated
• Subcellular Location: Nucleus
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot analysis of extracts from HepG2 cells, using CSRP2 Antibody. The lane on the left was treated with blocking peptide.)

Related Product Information for anti-CSRP2 antibody

Description: Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.

Subunit Structure: Interacts with KAT14. The LIM domain 1 is necessary and sufficient for this interaction. Interacts with GLRX3 (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 665821267
• NCBI GeneID: 1466
• NCBI Accession #: NP_001287894.1
• NCBI GenBank Nucleotide #: NP_001287894.1
• UniProt Accession #: Q16527
• Molecular Weight: Observed: 21 kDa; Predicted: 21 kDa
• NCBI Official Full Name: cysteine and glycine-rich protein 2
• NCBI Official Synonym Full Names: cysteine and glycine rich protein 2
• NCBI Official Symbol: CSRP2
• NCBI Official Synonym Symbols: CRP2; LMO5; SmLIM
• NCBI Protein Information: cysteine and glycine-rich protein 2
• UniProt Protein Name: Cysteine and glycine-rich protein 2
• Protein Family: Cysteine and glycine-rich protein
• UniProt Gene Name: CSRP2
• UniProt Synonym Gene Names: LMO5; SMLIM; CRP2; LMO-5; SmLIM
• UniProt Entry Name: CSRP2_HUMAN

NCBI Description

CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Description

CSRP2: a LIM protein that is differentially regulated and preferentially expressed in aortic smooth muscle cells. Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.

Protein type: Cell development/differentiation

Chromosomal Location of Human Ortholog: 12q21.1

Cellular Component: focal adhesion; nucleus

Molecular Function: zinc ion binding

Biological Process: multicellular organismal development; cell differentiation