Western Blot (WB)
(CRFR2 Antibody (D35) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CRFR2 antibody detected the CRFR2 protein (arrow).)
Rabbit anti-Human CRFR2 Polyclonal Antibody | anti-CRHR2 antibody
CRFR2 Antibody (D35)
IHC-P~~1:50 ~ 100
FC/FACS~~1:10 ~ 50
Western Blot (WB)
(CRFR2 Antibody (D35) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CRFR2 antibody detected the CRFR2 protein (arrow).)
Western Blot (WB)
(CRFR2 Antibody (D35) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CRFR2 antibody detected the CRFR2 protein (arrow).)
Immunohistochemistry (IHC)
(CRFR2 Antibody (D35) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CRFR2 Antibody (D35) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(CRFR2 Antibody (D35) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CRFR2 Antibody (D35) for immunohistochemistry. Clinical relevance has not been evaluated.)
Flow Cytometry (FC/FACS)
(CRFR2 Antibody (D35) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(CRFR2 Antibody (D35) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Gutknecht, E., et al. Eur. J. Pharmacol. 642 (1-3), 1-9 (2010) :
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
Joubert, B.R., et al. Genome Med 2 (3), 17 (2010) :
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]
Uniprot Description
CRHR2: This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 2; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 7p14.3
Cellular Component: Golgi apparatus; cell surface; integral to plasma membrane; endoplasmic reticulum; plasma membrane
Molecular Function: protein binding; hormone activity; corticotrophin-releasing factor receptor activity
Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; negative regulation of angiogenesis
Research Articles on CRHR2
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Product Notes
The CRHR2 crhr2 (Catalog #AAA9207506) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 10-39. The CRFR2 Antibody (D35) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CRFR2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS). WB~~1:1000 IHC-P~~1:50 ~ 100 FC/FACS~~1:10 ~ 50. Researchers should empirically determine the suitability of the CRHR2 crhr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CRFR2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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